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Neuroprotective Effect of ent-Kaur-15-en-17-al-18-oic Acid on Amyloid Beta Peptide-Induced Oxidative Apoptosis in Alzheimer’s Disease

ent-Kaur-15-en-17-al-18-oic acid, extracted from the Chinese well known folk herb Leontopodium longifolium, performed a significantly neuroprotective effect on amyloid beta peptide 25-35 (Aβ(25-35))-induced SH-SY5Y cells neurotoxicity in Alzheimer’s disease. The results demonstrated that this compou...

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Autores principales: Zhang, Caiyun, Zhao, Xingming, Lin, Shiqi, Liu, Fangyuan, Ma, Jiahui, Han, Zhuo, Jia, Fujuan, Xie, Weidong, Zhang, Qian, Li, Xia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6982857/
https://www.ncbi.nlm.nih.gov/pubmed/31905798
http://dx.doi.org/10.3390/molecules25010142
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author Zhang, Caiyun
Zhao, Xingming
Lin, Shiqi
Liu, Fangyuan
Ma, Jiahui
Han, Zhuo
Jia, Fujuan
Xie, Weidong
Zhang, Qian
Li, Xia
author_facet Zhang, Caiyun
Zhao, Xingming
Lin, Shiqi
Liu, Fangyuan
Ma, Jiahui
Han, Zhuo
Jia, Fujuan
Xie, Weidong
Zhang, Qian
Li, Xia
author_sort Zhang, Caiyun
collection PubMed
description ent-Kaur-15-en-17-al-18-oic acid, extracted from the Chinese well known folk herb Leontopodium longifolium, performed a significantly neuroprotective effect on amyloid beta peptide 25-35 (Aβ(25-35))-induced SH-SY5Y cells neurotoxicity in Alzheimer’s disease. The results demonstrated that this compound maintained oxidative stress balance, reduced levels of reactive oxygen species (ROS), malondialdehyde (MDA), and improved contents of glutathione (GSH) and superoxide dismutase (SOD) without obvious cytotoxicity. This compound also obviously relieved oxidative stress-induced apoptosis associated with p53 and nuclear factor κB (NF-κB) pathways accompanied by upregulating B-cell lymphoma-2 (bcl-2) and downregulating p53, nuclear factor κB (NF-κB), Bax, Cleaved-caspase 3, and Cytochrome C protein expressions further. Briefly, ent-kaur-15-en-17-al-18-oic acid protected cells from oxidative apoptosis associated with p53 and NF-κB pathways.
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spelling pubmed-69828572020-02-06 Neuroprotective Effect of ent-Kaur-15-en-17-al-18-oic Acid on Amyloid Beta Peptide-Induced Oxidative Apoptosis in Alzheimer’s Disease Zhang, Caiyun Zhao, Xingming Lin, Shiqi Liu, Fangyuan Ma, Jiahui Han, Zhuo Jia, Fujuan Xie, Weidong Zhang, Qian Li, Xia Molecules Article ent-Kaur-15-en-17-al-18-oic acid, extracted from the Chinese well known folk herb Leontopodium longifolium, performed a significantly neuroprotective effect on amyloid beta peptide 25-35 (Aβ(25-35))-induced SH-SY5Y cells neurotoxicity in Alzheimer’s disease. The results demonstrated that this compound maintained oxidative stress balance, reduced levels of reactive oxygen species (ROS), malondialdehyde (MDA), and improved contents of glutathione (GSH) and superoxide dismutase (SOD) without obvious cytotoxicity. This compound also obviously relieved oxidative stress-induced apoptosis associated with p53 and nuclear factor κB (NF-κB) pathways accompanied by upregulating B-cell lymphoma-2 (bcl-2) and downregulating p53, nuclear factor κB (NF-κB), Bax, Cleaved-caspase 3, and Cytochrome C protein expressions further. Briefly, ent-kaur-15-en-17-al-18-oic acid protected cells from oxidative apoptosis associated with p53 and NF-κB pathways. MDPI 2019-12-29 /pmc/articles/PMC6982857/ /pubmed/31905798 http://dx.doi.org/10.3390/molecules25010142 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zhang, Caiyun
Zhao, Xingming
Lin, Shiqi
Liu, Fangyuan
Ma, Jiahui
Han, Zhuo
Jia, Fujuan
Xie, Weidong
Zhang, Qian
Li, Xia
Neuroprotective Effect of ent-Kaur-15-en-17-al-18-oic Acid on Amyloid Beta Peptide-Induced Oxidative Apoptosis in Alzheimer’s Disease
title Neuroprotective Effect of ent-Kaur-15-en-17-al-18-oic Acid on Amyloid Beta Peptide-Induced Oxidative Apoptosis in Alzheimer’s Disease
title_full Neuroprotective Effect of ent-Kaur-15-en-17-al-18-oic Acid on Amyloid Beta Peptide-Induced Oxidative Apoptosis in Alzheimer’s Disease
title_fullStr Neuroprotective Effect of ent-Kaur-15-en-17-al-18-oic Acid on Amyloid Beta Peptide-Induced Oxidative Apoptosis in Alzheimer’s Disease
title_full_unstemmed Neuroprotective Effect of ent-Kaur-15-en-17-al-18-oic Acid on Amyloid Beta Peptide-Induced Oxidative Apoptosis in Alzheimer’s Disease
title_short Neuroprotective Effect of ent-Kaur-15-en-17-al-18-oic Acid on Amyloid Beta Peptide-Induced Oxidative Apoptosis in Alzheimer’s Disease
title_sort neuroprotective effect of ent-kaur-15-en-17-al-18-oic acid on amyloid beta peptide-induced oxidative apoptosis in alzheimer’s disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6982857/
https://www.ncbi.nlm.nih.gov/pubmed/31905798
http://dx.doi.org/10.3390/molecules25010142
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