Synthesis, Structural Characterization, and Biological Activity of New Pyrazolo[4,3-e][1,2,4]triazine Acyclonucleosides

A series of new pyrazolo[4,3-e][1,2,4]triazine acyclonucleosides 2–5 and 8 were prepared and evaluated for their anticancer activity against human cancer cell lines (MCF-7, K-562) and CDK2/E, as well as Abl protein kinases inhibitors. Lipophilicity of the compounds was determined using C-18 and immo...

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Detalles Bibliográficos
Autores principales: Mojzych, Mariusz, Bernat, Zofia, Karczmarzyk, Zbigniew, Matysiak, Joanna, Fruziński, Andrzej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6982861/
https://www.ncbi.nlm.nih.gov/pubmed/31948129
http://dx.doi.org/10.3390/molecules25010221

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6982861/
https://www.ncbi.nlm.nih.gov/pubmed/31948129
http://dx.doi.org/10.3390/molecules25010221

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