Cargando…

Protopine Protects Mice against LPS-Induced Acute Kidney Injury by Inhibiting Apoptosis and Inflammation via the TLR4 Signaling Pathway

Corydalis humosa Migo is a traditional Chinese medicine that clears away damp heat, relieves sore. Protopine (PRO) is an alkaloid component isolated from C. humosa Migo. However, the role of protopine in acute kidney injury (AKI) has not yet been reported. This study aims to investigate the effect a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Beibei, Zeng, Mengnan, Li, Meng, Kan, Yuxuan, Li, Benke, Xu, Ruiqi, Wu, Yuanyuan, Wang, Shengchao, Zheng, Xiaoke, Feng, Weisheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6982873/ https://www.ncbi.nlm.nih.gov/pubmed/31861525 http://dx.doi.org/10.3390/molecules25010015

Ejemplares similares

Adenosine Attenuates LPS-Induced Cardiac Dysfunction by Inhibition of Mitochondrial Function via the ER Pathway
por: Zeng, Mengnan, et al.
Publicado: (2019)

Corallodiscus flabellata B. L. Burtt extract alleviates lipopolysaccharide/D-galactosamine-induced acute liver failure and brain injury by inhibiting oxidative stress, apoptosis, and inflammation
por: Li, Benke, et al.
Publicado: (2020)

Acetone Extract of Cornus officinalis Leaves Exerts Anti-Melanoma Effects via Inhibiting STAT3 Signaling
por: Xu, Ruiqi, et al.
Publicado: (2021)

Corallodiscus flabellata B.L. Burtt Extracts Stimulate Diuretic Activity and Regulate the Renal Expression of Aquaporins
por: Kan, Yuxuan, et al.
Publicado: (2020)

Chrysosplenol D protects mice against LPS-induced acute lung injury by inhibiting oxidative stress, inflammation, and apoptosis via TLR4-MAPKs/NF-κB signaling pathways
por: Zhang, Qinqin, et al.
Publicado: (2021)

A sesquiterpene isolated from the stems and leaves of Dioscorea opposita thunb. Transforms the composition of immune cells through ERβ in a mouse model of LPS-induced lung injury
por: Zeng, Mengnan, et al.
Publicado: (2022)

Four New Benzoylamide Derivatives Isolated from the Seeds of Lepidium apetalum Willd. and Ameliorated LPS-Induced NRK52e Cells via Nrf2/Keap1 Pathway
por: Li, Meng, et al.
Publicado: (2022)

2-Phenylacetamide Isolated from the Seeds of Lepidium apetalum and Its Estrogen-Like Effects In Vitro and In Vivo
por: Zeng, Mengnan, et al.
Publicado: (2018)

Cytotoxicity of Aporphine, Protoberberine, and Protopine Alkaloids from Dicranostigma leptopodum (Maxim.) Fedde
por: Sun, Ruiqi, et al.
Publicado: (2014)

Bromo-protopine, a novel protopine derivative, alleviates tau pathology by activating chaperone-mediated autophagy for Alzheimer’s disease therapy
por: Sreenivasmurthy, Sravan Gopalkrishnashetty, et al.
Publicado: (2022)

In vitro Non-Small Cell Lung Cancer Inhibitory Effect by New Diphenylethane Isolated From Stems and Leaves of Dioscorea oppositifolia L. via ERβ-STAT3 Pathway
por: Zeng, Mengnan, et al.
Publicado: (2021)

Epimedium sagittatum Maxim ameliorates adriamycin‐induced nephropathy by restraining inflammation and apoptosis via the PI3K/AKT signaling pathway
por: Wang, Ru, et al.
Publicado: (2023)

Extract of Corallodiscus flabellata attenuates renal fibrosis in SAMP8 mice via the Wnt/β-catenin/RAS signaling pathway
por: Cao, Bing, et al.
Publicado: (2022)

Administration of protopine prevents mitophagy and acute lung injury in sepsis
por: Xiao, Zhong, et al.
Publicado: (2023)

Placental Passage of Protopine in an Ex Vivo Human Perfusion System
por: Spiess, Deborah, et al.
Publicado: (2022)

Eriodictyol and Homoeriodictyol Improve Memory Impairment in Aβ(25–35)-Induced Mice by Inhibiting the NLRP3 Inflammasome
por: Guo, Pengli, et al.
Publicado: (2022)

Lepidiumuridine A: A New Natural Uridine Derivative as a Phytoestrogen Isolated from the Seeds of Lepidium apetalum Willd.
por: Li, Meng, et al.
Publicado: (2018)

Exploring the Anti-inflammatory Effects of Protopine Total Alkaloids of Macleaya Cordata (Willd.) R. Br.
por: Dong, Zhen, et al.
Publicado: (2022)

In Vivo Anticonvulsant Activity of Extracts and Protopine from the Fumaria schleicheri Herb
por: Prokopenko, Yuliya, et al.
Publicado: (2015)

Placental Passage of Humulone and Protopine in an Ex Vivo Human Perfusion System
por: Spiess, Deborah, et al.
Publicado: (2021)

Estrogenic Effects of the Extracts from the Chinese Yam (Dioscorea opposite Thunb.) and Its Effective Compounds in Vitro and in Vivo
por: Zeng, Mengnan, et al.
Publicado: (2018)

Acute, chronic, and genotoxic studies on the protopine total alkaloids of the Macleaya cordata (willd.) R. Br. in rodents
por: Dong, Zhen, et al.
Publicado: (2022)

Effect of Wine and Vinegar Processing of Rhizoma Corydalis on the Tissue Distribution of Tetrahydropalmatine, Protopine and Dehydrocorydaline in Rats
por: Dou, Zhiying, et al.
Publicado: (2012)

Protopine triggers apoptosis via the intrinsic pathway and regulation of ROS/PI3K/Akt signalling pathway in liver carcinoma
por: Nie, Chunhui, et al.
Publicado: (2021)

An Amide Alkaloid Isolated from Ephedra sinica Ameliorates OVA-Induced Allergic Asthma by Inhibiting Mast Cell Activation and Dendritic Cell Maturation
por: Jia, Jufang, et al.
Publicado: (2022)

Identification and Quantification, Metabolism and Pharmacokinetics, Pharmacological Activities, and Botanical Preparations of Protopine: A Review
por: Huang, Wangli, et al.
Publicado: (2021)

Effects of three types of fresh Rehmannia glutinosa improve lipopolysaccharide-induced acute kidney injury in sepsis through the estrogen receptor pathway
por: Liu, Meng, et al.
Publicado: (2023)

Biotransformation and tissue distribution of protopine and allocryptopine and effects of Plume Poppy Total Alkaloid on liver drug-metabolizing enzymes
por: Huang, Ya-Jun, et al.
Publicado: (2018)

Protopine Alleviates Dextran Sodium Sulfate-Induced Ulcerative Colitis by Improving Intestinal Barrier Function and Regulating Intestinal Microbiota
por: Yue, Meishan, et al.
Publicado: (2023)

Potential Toxicity Evaluation of Protopine in Macleaya cordata (Willd.) R. Br.—A Bioactivity Guided Approach
por: Hu, Wanjun, et al.
Publicado: (2021)

Anti-Pulmonary Fibrosis Activities of Triterpenoids from Oenothera biennis
por: Liu, Juanjuan, et al.
Publicado: (2022)

Hyperin protects against LPS-induced acute kidney injury by inhibiting TLR4 and NLRP3 signaling pathways
por: Chunzhi, Gong, et al.
Publicado: (2016)

Upregulation of TLR4-Dependent ATP Production Is Critical for Glaesserella parasuis LPS-Mediated Inflammation
por: Liu, Fei, et al.
Publicado: (2023)

Stem Cell-Induced Inflammation in Cholesteatoma Is Inhibited by the TLR4 Antagonist LPS-RS
por: Schürmann, Matthias, et al.
Publicado: (2020)

Overabundance of Veillonella parvula promotes intestinal inflammation by activating macrophages via LPS-TLR4 pathway
por: Zhan, Zhiyan, et al.
Publicado: (2022)

Betaine Alleviates LPS-Induced Chicken Skeletal Muscle Inflammation with the Epigenetic Modulation of the TLR4 Gene
por: Guo, Feng, et al.
Publicado: (2022)

Rifampicin improves neuronal apoptosis in LPS-stimulated co-cultured BV2 cells through inhibition of the TLR-4 pathway
por: BI, WEI, et al.
Publicado: (2014)

Association between TLR4 and PTEN Involved in LPS-TLR4 Signaling Response
por: Yin, Huahua, et al.
Publicado: (2016)

Central composite design expert-supported development and validation of HPTLC method: Relevance in quantitative evaluation of protopine in Fumaria indica
por: Ahmad, Ajaz, et al.
Publicado: (2020)

Anti-Inflammatory Effect of Protopine through MAPK and NF-κB Signaling Regulation in HepG2 Cell
por: Kim, MinGyu, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_o2vgs3i13gephqvhcvg73hfb35