Hyalodendrins A and B, New Decalin-Type Tetramic Acid Larvicides from the Endophytic Fungus Hyalodendriella sp. Ponipodef12

Two new decalin/tetramic acid hybrid metabolites, hyalodendrins A (1) and B (2) were isolated from plant endophytic fungus Hyalodendriella sp. Ponipodef12. The structures of the new compounds were elucidated by analysis of the spectroscopic data, including NMR, HRMS and ECD, and by chemical conversi...

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Autores principales: Mao, Ziling, Wang, Weixuan, Su, Ruixue, Gu, Gan, Liu, Zhi Long, Lai, Daowan, Zhou, Ligang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6982915/
https://www.ncbi.nlm.nih.gov/pubmed/31892246
http://dx.doi.org/10.3390/molecules25010114
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author Mao, Ziling
Wang, Weixuan
Su, Ruixue
Gu, Gan
Liu, Zhi Long
Lai, Daowan
Zhou, Ligang
author_facet Mao, Ziling
Wang, Weixuan
Su, Ruixue
Gu, Gan
Liu, Zhi Long
Lai, Daowan
Zhou, Ligang
author_sort Mao, Ziling
collection PubMed
description Two new decalin/tetramic acid hybrid metabolites, hyalodendrins A (1) and B (2) were isolated from plant endophytic fungus Hyalodendriella sp. Ponipodef12. The structures of the new compounds were elucidated by analysis of the spectroscopic data, including NMR, HRMS and ECD, and by chemical conversion. Compounds 1 and 2 were phomasetin analogues, and both showed potent larvicidal activity against the fourth-instar larvae of Aedes aegypti with the median lethal dose (LC(50)) values of 10.31 and 5.93 μg/mL, respectively.
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spelling pubmed-69829152020-02-06 Hyalodendrins A and B, New Decalin-Type Tetramic Acid Larvicides from the Endophytic Fungus Hyalodendriella sp. Ponipodef12 Mao, Ziling Wang, Weixuan Su, Ruixue Gu, Gan Liu, Zhi Long Lai, Daowan Zhou, Ligang Molecules Article Two new decalin/tetramic acid hybrid metabolites, hyalodendrins A (1) and B (2) were isolated from plant endophytic fungus Hyalodendriella sp. Ponipodef12. The structures of the new compounds were elucidated by analysis of the spectroscopic data, including NMR, HRMS and ECD, and by chemical conversion. Compounds 1 and 2 were phomasetin analogues, and both showed potent larvicidal activity against the fourth-instar larvae of Aedes aegypti with the median lethal dose (LC(50)) values of 10.31 and 5.93 μg/mL, respectively. MDPI 2019-12-27 /pmc/articles/PMC6982915/ /pubmed/31892246 http://dx.doi.org/10.3390/molecules25010114 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mao, Ziling
Wang, Weixuan
Su, Ruixue
Gu, Gan
Liu, Zhi Long
Lai, Daowan
Zhou, Ligang
Hyalodendrins A and B, New Decalin-Type Tetramic Acid Larvicides from the Endophytic Fungus Hyalodendriella sp. Ponipodef12
title Hyalodendrins A and B, New Decalin-Type Tetramic Acid Larvicides from the Endophytic Fungus Hyalodendriella sp. Ponipodef12
title_full Hyalodendrins A and B, New Decalin-Type Tetramic Acid Larvicides from the Endophytic Fungus Hyalodendriella sp. Ponipodef12
title_fullStr Hyalodendrins A and B, New Decalin-Type Tetramic Acid Larvicides from the Endophytic Fungus Hyalodendriella sp. Ponipodef12
title_full_unstemmed Hyalodendrins A and B, New Decalin-Type Tetramic Acid Larvicides from the Endophytic Fungus Hyalodendriella sp. Ponipodef12
title_short Hyalodendrins A and B, New Decalin-Type Tetramic Acid Larvicides from the Endophytic Fungus Hyalodendriella sp. Ponipodef12
title_sort hyalodendrins a and b, new decalin-type tetramic acid larvicides from the endophytic fungus hyalodendriella sp. ponipodef12
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6982915/
https://www.ncbi.nlm.nih.gov/pubmed/31892246
http://dx.doi.org/10.3390/molecules25010114
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