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Can immunohistochemical biomarkers distinguish epithelial dysplasia degrees in actinic cheilitis? A systematic review and meta-analysis
BACKGROUND: Actinic cheilitis (AC) is a poten-tially malignant disorder of the lip, characterized by epithelial and connective tissue alterations caused by chronic exposure to ultraviolet radiation. In the past decades, diverse studies have been conducted in lip carcinogenesis and many biomarkers ha...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medicina Oral S.L.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6982981/ https://www.ncbi.nlm.nih.gov/pubmed/31880283 http://dx.doi.org/10.4317/medoral.23223 |
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author | Santana, Thalita Matuck, Bruno Tenório, Jefferson R. Braga, Mariana Minatel |
author_facet | Santana, Thalita Matuck, Bruno Tenório, Jefferson R. Braga, Mariana Minatel |
author_sort | Santana, Thalita |
collection | PubMed |
description | BACKGROUND: Actinic cheilitis (AC) is a poten-tially malignant disorder of the lip, characterized by epithelial and connective tissue alterations caused by chronic exposure to ultraviolet radiation. In the past decades, diverse studies have been conducted in lip carcinogenesis and many biomarkers have been identified in lip lesions, yet there is no scientific evidence that determines its usefulness in the clinical setting or in histopatho-logical routine. Therefore, we conducted the first systematic review in this field to summarize the results of published studies on immunohistochemical bi-omarkers in lip carcinogenesis, to evaluate if there is a marker than can distin-guish the different histological grades of AC. MATERIAL AND METHODS: Retrospective stud-ies that investigated immunohistochemical biomarkers in AC defined on standardised histological assessment were gathered from five databases and evaluated. Each study was qualitatively evaluated using the Critical Appraisal Tools from SUMARI. RESULTS: The proliferation marker Ki-67 was the most studied biomarker and we observed, through meta-analysis, that it was differently expressed between AC and lip cancer, but not in AC sub-groups. Most articles had a high risk of bias. CONCLUSIONS: In summary, the literature lacks quality follow up studies in actinic cheilitis. Multi-centre cohort studies, with patients stratified by treatment type and the use of image analysis soft-ware, could be the solution to further address the issues of investigating poten-tially malignant lesions and help change clinical practice, in terms of individu-alizing patients’ treatment and prognosis prediction. Key words:Lip carcinogenesis, actinic cheilitis, lip cancer, bi-omarkers. |
format | Online Article Text |
id | pubmed-6982981 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Medicina Oral S.L. |
record_format | MEDLINE/PubMed |
spelling | pubmed-69829812020-01-29 Can immunohistochemical biomarkers distinguish epithelial dysplasia degrees in actinic cheilitis? A systematic review and meta-analysis Santana, Thalita Matuck, Bruno Tenório, Jefferson R. Braga, Mariana Minatel Med Oral Patol Oral Cir Bucal Review BACKGROUND: Actinic cheilitis (AC) is a poten-tially malignant disorder of the lip, characterized by epithelial and connective tissue alterations caused by chronic exposure to ultraviolet radiation. In the past decades, diverse studies have been conducted in lip carcinogenesis and many biomarkers have been identified in lip lesions, yet there is no scientific evidence that determines its usefulness in the clinical setting or in histopatho-logical routine. Therefore, we conducted the first systematic review in this field to summarize the results of published studies on immunohistochemical bi-omarkers in lip carcinogenesis, to evaluate if there is a marker than can distin-guish the different histological grades of AC. MATERIAL AND METHODS: Retrospective stud-ies that investigated immunohistochemical biomarkers in AC defined on standardised histological assessment were gathered from five databases and evaluated. Each study was qualitatively evaluated using the Critical Appraisal Tools from SUMARI. RESULTS: The proliferation marker Ki-67 was the most studied biomarker and we observed, through meta-analysis, that it was differently expressed between AC and lip cancer, but not in AC sub-groups. Most articles had a high risk of bias. CONCLUSIONS: In summary, the literature lacks quality follow up studies in actinic cheilitis. Multi-centre cohort studies, with patients stratified by treatment type and the use of image analysis soft-ware, could be the solution to further address the issues of investigating poten-tially malignant lesions and help change clinical practice, in terms of individu-alizing patients’ treatment and prognosis prediction. Key words:Lip carcinogenesis, actinic cheilitis, lip cancer, bi-omarkers. Medicina Oral S.L. 2020-01 2019-12-24 /pmc/articles/PMC6982981/ /pubmed/31880283 http://dx.doi.org/10.4317/medoral.23223 Text en Copyright: © 2020 Medic-ina Oral S.L. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons At-tribution License, which permits unrestricted use, distribution, and reproduc-tion in any medium, provided the original work is properly cited. |
spellingShingle | Review Santana, Thalita Matuck, Bruno Tenório, Jefferson R. Braga, Mariana Minatel Can immunohistochemical biomarkers distinguish epithelial dysplasia degrees in actinic cheilitis? A systematic review and meta-analysis |
title | Can immunohistochemical biomarkers distinguish epithelial dysplasia degrees in actinic cheilitis? A systematic review and meta-analysis |
title_full | Can immunohistochemical biomarkers distinguish epithelial dysplasia degrees in actinic cheilitis? A systematic review and meta-analysis |
title_fullStr | Can immunohistochemical biomarkers distinguish epithelial dysplasia degrees in actinic cheilitis? A systematic review and meta-analysis |
title_full_unstemmed | Can immunohistochemical biomarkers distinguish epithelial dysplasia degrees in actinic cheilitis? A systematic review and meta-analysis |
title_short | Can immunohistochemical biomarkers distinguish epithelial dysplasia degrees in actinic cheilitis? A systematic review and meta-analysis |
title_sort | can immunohistochemical biomarkers distinguish epithelial dysplasia degrees in actinic cheilitis? a systematic review and meta-analysis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6982981/ https://www.ncbi.nlm.nih.gov/pubmed/31880283 http://dx.doi.org/10.4317/medoral.23223 |
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