Cargando…

Can immunohistochemical biomarkers distinguish epithelial dysplasia degrees in actinic cheilitis? A systematic review and meta-analysis

BACKGROUND: Actinic cheilitis (AC) is a poten-tially malignant disorder of the lip, characterized by epithelial and connective tissue alterations caused by chronic exposure to ultraviolet radiation. In the past decades, diverse studies have been conducted in lip carcinogenesis and many biomarkers ha...

Descripción completa

Detalles Bibliográficos
Autores principales: Santana, Thalita, Matuck, Bruno, Tenório, Jefferson R., Braga, Mariana Minatel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medicina Oral S.L. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6982981/
https://www.ncbi.nlm.nih.gov/pubmed/31880283
http://dx.doi.org/10.4317/medoral.23223
_version_ 1783491414348267520
author Santana, Thalita
Matuck, Bruno
Tenório, Jefferson R.
Braga, Mariana Minatel
author_facet Santana, Thalita
Matuck, Bruno
Tenório, Jefferson R.
Braga, Mariana Minatel
author_sort Santana, Thalita
collection PubMed
description BACKGROUND: Actinic cheilitis (AC) is a poten-tially malignant disorder of the lip, characterized by epithelial and connective tissue alterations caused by chronic exposure to ultraviolet radiation. In the past decades, diverse studies have been conducted in lip carcinogenesis and many biomarkers have been identified in lip lesions, yet there is no scientific evidence that determines its usefulness in the clinical setting or in histopatho-logical routine. Therefore, we conducted the first systematic review in this field to summarize the results of published studies on immunohistochemical bi-omarkers in lip carcinogenesis, to evaluate if there is a marker than can distin-guish the different histological grades of AC. MATERIAL AND METHODS: Retrospective stud-ies that investigated immunohistochemical biomarkers in AC defined on standardised histological assessment were gathered from five databases and evaluated. Each study was qualitatively evaluated using the Critical Appraisal Tools from SUMARI. RESULTS: The proliferation marker Ki-67 was the most studied biomarker and we observed, through meta-analysis, that it was differently expressed between AC and lip cancer, but not in AC sub-groups. Most articles had a high risk of bias. CONCLUSIONS: In summary, the literature lacks quality follow up studies in actinic cheilitis. Multi-centre cohort studies, with patients stratified by treatment type and the use of image analysis soft-ware, could be the solution to further address the issues of investigating poten-tially malignant lesions and help change clinical practice, in terms of individu-alizing patients’ treatment and prognosis prediction. Key words:Lip carcinogenesis, actinic cheilitis, lip cancer, bi-omarkers.
format Online
Article
Text
id pubmed-6982981
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Medicina Oral S.L.
record_format MEDLINE/PubMed
spelling pubmed-69829812020-01-29 Can immunohistochemical biomarkers distinguish epithelial dysplasia degrees in actinic cheilitis? A systematic review and meta-analysis Santana, Thalita Matuck, Bruno Tenório, Jefferson R. Braga, Mariana Minatel Med Oral Patol Oral Cir Bucal Review BACKGROUND: Actinic cheilitis (AC) is a poten-tially malignant disorder of the lip, characterized by epithelial and connective tissue alterations caused by chronic exposure to ultraviolet radiation. In the past decades, diverse studies have been conducted in lip carcinogenesis and many biomarkers have been identified in lip lesions, yet there is no scientific evidence that determines its usefulness in the clinical setting or in histopatho-logical routine. Therefore, we conducted the first systematic review in this field to summarize the results of published studies on immunohistochemical bi-omarkers in lip carcinogenesis, to evaluate if there is a marker than can distin-guish the different histological grades of AC. MATERIAL AND METHODS: Retrospective stud-ies that investigated immunohistochemical biomarkers in AC defined on standardised histological assessment were gathered from five databases and evaluated. Each study was qualitatively evaluated using the Critical Appraisal Tools from SUMARI. RESULTS: The proliferation marker Ki-67 was the most studied biomarker and we observed, through meta-analysis, that it was differently expressed between AC and lip cancer, but not in AC sub-groups. Most articles had a high risk of bias. CONCLUSIONS: In summary, the literature lacks quality follow up studies in actinic cheilitis. Multi-centre cohort studies, with patients stratified by treatment type and the use of image analysis soft-ware, could be the solution to further address the issues of investigating poten-tially malignant lesions and help change clinical practice, in terms of individu-alizing patients’ treatment and prognosis prediction. Key words:Lip carcinogenesis, actinic cheilitis, lip cancer, bi-omarkers. Medicina Oral S.L. 2020-01 2019-12-24 /pmc/articles/PMC6982981/ /pubmed/31880283 http://dx.doi.org/10.4317/medoral.23223 Text en Copyright: © 2020 Medic-ina Oral S.L. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons At-tribution License, which permits unrestricted use, distribution, and reproduc-tion in any medium, provided the original work is properly cited.
spellingShingle Review
Santana, Thalita
Matuck, Bruno
Tenório, Jefferson R.
Braga, Mariana Minatel
Can immunohistochemical biomarkers distinguish epithelial dysplasia degrees in actinic cheilitis? A systematic review and meta-analysis
title Can immunohistochemical biomarkers distinguish epithelial dysplasia degrees in actinic cheilitis? A systematic review and meta-analysis
title_full Can immunohistochemical biomarkers distinguish epithelial dysplasia degrees in actinic cheilitis? A systematic review and meta-analysis
title_fullStr Can immunohistochemical biomarkers distinguish epithelial dysplasia degrees in actinic cheilitis? A systematic review and meta-analysis
title_full_unstemmed Can immunohistochemical biomarkers distinguish epithelial dysplasia degrees in actinic cheilitis? A systematic review and meta-analysis
title_short Can immunohistochemical biomarkers distinguish epithelial dysplasia degrees in actinic cheilitis? A systematic review and meta-analysis
title_sort can immunohistochemical biomarkers distinguish epithelial dysplasia degrees in actinic cheilitis? a systematic review and meta-analysis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6982981/
https://www.ncbi.nlm.nih.gov/pubmed/31880283
http://dx.doi.org/10.4317/medoral.23223
work_keys_str_mv AT santanathalita canimmunohistochemicalbiomarkersdistinguishepithelialdysplasiadegreesinactiniccheilitisasystematicreviewandmetaanalysis
AT matuckbruno canimmunohistochemicalbiomarkersdistinguishepithelialdysplasiadegreesinactiniccheilitisasystematicreviewandmetaanalysis
AT tenoriojeffersonr canimmunohistochemicalbiomarkersdistinguishepithelialdysplasiadegreesinactiniccheilitisasystematicreviewandmetaanalysis
AT bragamarianaminatel canimmunohistochemicalbiomarkersdistinguishepithelialdysplasiadegreesinactiniccheilitisasystematicreviewandmetaanalysis