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CD1a+ and CD207+ cells are reduced in oral submucous fibrosis and oral squamous cell carcinoma
BACKGROUND: The objective of this study investigated the distribution of immature dendritic cells (DCs), Langerhans cells and plasmacytoid DCs in oral submucous fibrosis (OSMF), OSMF associated with oral squamous cell carcinoma (OSMF-OSCC), oral leukoplakia (OL), and oral squamous cell carcinoma (OS...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medicina Oral S.L.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6982989/ https://www.ncbi.nlm.nih.gov/pubmed/31880289 http://dx.doi.org/10.4317/medoral.23177 |
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author | da Silva, Luan César Fonseca, Felipe Paiva de Almeida, Oslei Paes Mariz, Bruno Augusto Linhares de Almeida Lopes, Márcio Ajudarte Radhakrishnan, Raghu Sharma, Mohit Kowalski, Luiz Paulo Vargas, Pablo Agustin |
author_facet | da Silva, Luan César Fonseca, Felipe Paiva de Almeida, Oslei Paes Mariz, Bruno Augusto Linhares de Almeida Lopes, Márcio Ajudarte Radhakrishnan, Raghu Sharma, Mohit Kowalski, Luiz Paulo Vargas, Pablo Agustin |
author_sort | da Silva, Luan César |
collection | PubMed |
description | BACKGROUND: The objective of this study investigated the distribution of immature dendritic cells (DCs), Langerhans cells and plasmacytoid DCs in oral submucous fibrosis (OSMF), OSMF associated with oral squamous cell carcinoma (OSMF-OSCC), oral leukoplakia (OL), and oral squamous cell carcinoma (OSCC). MATERIAL AND METHODS: Fourteen cases of OSMF, 9 of OSMF-OSCC, 8 of OL¸ 45 of OSCC and 8 of normal epithelium were retrospectively retrieved and their diagnoses confirmed. Immunoreactions against CD1a, CD207 e CD303 were performed and the number of positive cells quantified. RESULTS: A significant decrease of CD1a+ was found in OSMF (p≤0.05), OSMF-OSCC (p ≤ 0.01), and OSCC (p ≤ 0.001) when compared to normal epithelium. For CD207+ the significance decrease was observed in OSMF-OSCC (p ≤ 0.05), and OSCC (p ≤ 0.01) when compared with normal epithelium, and in OSMF when compared with OL (p ≤ 0.05). There was no significant difference for CD303, but increased in CD303+ was observed in OSCC when compared with normal epithelium. CONCLUSIONS: The decrease in the number of CD1a+ and CD207+ cells may be associate to the development of oral OSCC, and in OPMDs they might be indicators of malignant transformation. Key words:Premalignant lesions, oral submucous fibrosis, oral squamous cell carcinoma, immune response. |
format | Online Article Text |
id | pubmed-6982989 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Medicina Oral S.L. |
record_format | MEDLINE/PubMed |
spelling | pubmed-69829892020-01-29 CD1a+ and CD207+ cells are reduced in oral submucous fibrosis and oral squamous cell carcinoma da Silva, Luan César Fonseca, Felipe Paiva de Almeida, Oslei Paes Mariz, Bruno Augusto Linhares de Almeida Lopes, Márcio Ajudarte Radhakrishnan, Raghu Sharma, Mohit Kowalski, Luiz Paulo Vargas, Pablo Agustin Med Oral Patol Oral Cir Bucal Research BACKGROUND: The objective of this study investigated the distribution of immature dendritic cells (DCs), Langerhans cells and plasmacytoid DCs in oral submucous fibrosis (OSMF), OSMF associated with oral squamous cell carcinoma (OSMF-OSCC), oral leukoplakia (OL), and oral squamous cell carcinoma (OSCC). MATERIAL AND METHODS: Fourteen cases of OSMF, 9 of OSMF-OSCC, 8 of OL¸ 45 of OSCC and 8 of normal epithelium were retrospectively retrieved and their diagnoses confirmed. Immunoreactions against CD1a, CD207 e CD303 were performed and the number of positive cells quantified. RESULTS: A significant decrease of CD1a+ was found in OSMF (p≤0.05), OSMF-OSCC (p ≤ 0.01), and OSCC (p ≤ 0.001) when compared to normal epithelium. For CD207+ the significance decrease was observed in OSMF-OSCC (p ≤ 0.05), and OSCC (p ≤ 0.01) when compared with normal epithelium, and in OSMF when compared with OL (p ≤ 0.05). There was no significant difference for CD303, but increased in CD303+ was observed in OSCC when compared with normal epithelium. CONCLUSIONS: The decrease in the number of CD1a+ and CD207+ cells may be associate to the development of oral OSCC, and in OPMDs they might be indicators of malignant transformation. Key words:Premalignant lesions, oral submucous fibrosis, oral squamous cell carcinoma, immune response. Medicina Oral S.L. 2020-01 2019-12-24 /pmc/articles/PMC6982989/ /pubmed/31880289 http://dx.doi.org/10.4317/medoral.23177 Text en Copyright: © 2020 Medicina Oral S.L. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research da Silva, Luan César Fonseca, Felipe Paiva de Almeida, Oslei Paes Mariz, Bruno Augusto Linhares de Almeida Lopes, Márcio Ajudarte Radhakrishnan, Raghu Sharma, Mohit Kowalski, Luiz Paulo Vargas, Pablo Agustin CD1a+ and CD207+ cells are reduced in oral submucous fibrosis and oral squamous cell carcinoma |
title | CD1a+ and CD207+ cells are reduced in oral submucous fibrosis and oral squamous cell carcinoma |
title_full | CD1a+ and CD207+ cells are reduced in oral submucous fibrosis and oral squamous cell carcinoma |
title_fullStr | CD1a+ and CD207+ cells are reduced in oral submucous fibrosis and oral squamous cell carcinoma |
title_full_unstemmed | CD1a+ and CD207+ cells are reduced in oral submucous fibrosis and oral squamous cell carcinoma |
title_short | CD1a+ and CD207+ cells are reduced in oral submucous fibrosis and oral squamous cell carcinoma |
title_sort | cd1a+ and cd207+ cells are reduced in oral submucous fibrosis and oral squamous cell carcinoma |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6982989/ https://www.ncbi.nlm.nih.gov/pubmed/31880289 http://dx.doi.org/10.4317/medoral.23177 |
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