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Identification and Biological Evaluation of CK2 Allosteric Fragments through Structure-Based Virtual Screening
Casein kinase II (CK2) is considered as an attractive cancer therapeutic target, and recent efforts have been made to develop its ATP-competitive inhibitors. However, achieving selectivity with respect to related kinases remains challenging due to the highly conserved ATP-binding pocket of kinases....
Autores principales: | Li, Chunqiong, Zhang, Xuewen, Zhang, Na, Zhou, Yue, Sun, Guohui, Zhao, Lijiao, Zhong, Rugang |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6983002/ https://www.ncbi.nlm.nih.gov/pubmed/31935979 http://dx.doi.org/10.3390/molecules25010237 |
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