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Evaluation Procoagulant Activity and Mechanism of Astragalin

Astragalin, isolated from flowers of Rosa chinensis Jacq., is a kind of flavonoid, with anti-inflammatory, antioxidant, antiviral, analgesic, antibacterial, antiallergic, and antihepatotoxic effects. However, no studieson the procoagulant effect of astragalin have been reported. This study aimed to...

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Autores principales: Li, Changqin, Hu, Miyun, Jiang, Shengjun, Liang, Zhenhua, Wang, Jinmei, Liu, Zhenhua, Wang, Hui-Min David, Kang, Wenyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6983018/
https://www.ncbi.nlm.nih.gov/pubmed/31906332
http://dx.doi.org/10.3390/molecules25010177
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author Li, Changqin
Hu, Miyun
Jiang, Shengjun
Liang, Zhenhua
Wang, Jinmei
Liu, Zhenhua
Wang, Hui-Min David
Kang, Wenyi
author_facet Li, Changqin
Hu, Miyun
Jiang, Shengjun
Liang, Zhenhua
Wang, Jinmei
Liu, Zhenhua
Wang, Hui-Min David
Kang, Wenyi
author_sort Li, Changqin
collection PubMed
description Astragalin, isolated from flowers of Rosa chinensis Jacq., is a kind of flavonoid, with anti-inflammatory, antioxidant, antiviral, analgesic, antibacterial, antiallergic, and antihepatotoxic effects. However, no studieson the procoagulant effect of astragalin have been reported. This study aimed to investigate the procoagulant activity of astragalin and its mechanism. Its procoagulant effect was investigated by activated partial thromboplastin time (APTT), thrombin time (TT), prothrombin time (PT), and fibrinogen (FIB) in vitro, and a rat model established by heparin sodium was used to evaluate the mechanism for the procoagulant effect in vivo. The results showed that astragalin had good procoagulant effects compared with the control group in vitro. Compared with the model group in vivo, astragalin could shorten the coagulation time and significantly increase the number of platelets. Meanwhile, astragalin could significantly reduce the effectual time of PT and APTT and increase the content of FIB. The contents of 6-keto-PGF(1α) and eNOS significantly decreased. Astragalin could increase whole blood viscosity (WBV), plasma viscosity (PV), erythrocyte sedimentation rate (ESR) and packedcell volume (PCV). All of the above revealed that astragalin had good procoagulant effects by promoting the intrinsic and extrinsic coagulation system.
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spelling pubmed-69830182020-02-06 Evaluation Procoagulant Activity and Mechanism of Astragalin Li, Changqin Hu, Miyun Jiang, Shengjun Liang, Zhenhua Wang, Jinmei Liu, Zhenhua Wang, Hui-Min David Kang, Wenyi Molecules Article Astragalin, isolated from flowers of Rosa chinensis Jacq., is a kind of flavonoid, with anti-inflammatory, antioxidant, antiviral, analgesic, antibacterial, antiallergic, and antihepatotoxic effects. However, no studieson the procoagulant effect of astragalin have been reported. This study aimed to investigate the procoagulant activity of astragalin and its mechanism. Its procoagulant effect was investigated by activated partial thromboplastin time (APTT), thrombin time (TT), prothrombin time (PT), and fibrinogen (FIB) in vitro, and a rat model established by heparin sodium was used to evaluate the mechanism for the procoagulant effect in vivo. The results showed that astragalin had good procoagulant effects compared with the control group in vitro. Compared with the model group in vivo, astragalin could shorten the coagulation time and significantly increase the number of platelets. Meanwhile, astragalin could significantly reduce the effectual time of PT and APTT and increase the content of FIB. The contents of 6-keto-PGF(1α) and eNOS significantly decreased. Astragalin could increase whole blood viscosity (WBV), plasma viscosity (PV), erythrocyte sedimentation rate (ESR) and packedcell volume (PCV). All of the above revealed that astragalin had good procoagulant effects by promoting the intrinsic and extrinsic coagulation system. MDPI 2020-01-01 /pmc/articles/PMC6983018/ /pubmed/31906332 http://dx.doi.org/10.3390/molecules25010177 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Li, Changqin
Hu, Miyun
Jiang, Shengjun
Liang, Zhenhua
Wang, Jinmei
Liu, Zhenhua
Wang, Hui-Min David
Kang, Wenyi
Evaluation Procoagulant Activity and Mechanism of Astragalin
title Evaluation Procoagulant Activity and Mechanism of Astragalin
title_full Evaluation Procoagulant Activity and Mechanism of Astragalin
title_fullStr Evaluation Procoagulant Activity and Mechanism of Astragalin
title_full_unstemmed Evaluation Procoagulant Activity and Mechanism of Astragalin
title_short Evaluation Procoagulant Activity and Mechanism of Astragalin
title_sort evaluation procoagulant activity and mechanism of astragalin
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6983018/
https://www.ncbi.nlm.nih.gov/pubmed/31906332
http://dx.doi.org/10.3390/molecules25010177
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