Carbazole Alkaloids from Clausena anisum-olens: Isolation, Characterization, and Anti-HIV Evaluation

Two new carbazole alkaloids (1,2) and six known carbazole alkaloids (3–8) were isolated from Clausena anisum-olens. Their structures were elucidated based on extensive spectroscopic analysis. All isolated compounds (1–8) were evaluated for their anti-HIV effects on virus replication in MT-4 lymphocy...

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Detalles Bibliográficos
Autores principales: Yang, Jing-Hua, Wang, Xin-Yi, Zhou, Yi-Ping, Lu, Rong, Chen, Chin-Ho, Zhang, Meng-Han, Cheng, Yung-Yi, Morris-Natschke, Susan L., Lee, Kuo-Hsiung, Wang, Yun-Song
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6983056/
https://www.ncbi.nlm.nih.gov/pubmed/31888067
http://dx.doi.org/10.3390/molecules25010099
Descripción
Sumario:Two new carbazole alkaloids (1,2) and six known carbazole alkaloids (3–8) were isolated from Clausena anisum-olens. Their structures were elucidated based on extensive spectroscopic analysis. All isolated compounds (1–8) were evaluated for their anti-HIV effects on virus replication in MT-4 lymphocytes infected by HIV-1(NL4-3) Nanoluc-sec virus, and new carbazole alkaloid 1 exhibited anti-HIV activity with an EC(50) value of 2.4 μg/mL and SI of 7.1.

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