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Carbazole Alkaloids from Clausena anisum-olens: Isolation, Characterization, and Anti-HIV Evaluation
Two new carbazole alkaloids (1,2) and six known carbazole alkaloids (3–8) were isolated from Clausena anisum-olens. Their structures were elucidated based on extensive spectroscopic analysis. All isolated compounds (1–8) were evaluated for their anti-HIV effects on virus replication in MT-4 lymphocy...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6983056/ https://www.ncbi.nlm.nih.gov/pubmed/31888067 http://dx.doi.org/10.3390/molecules25010099 |
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| author | Yang, Jing-Hua Wang, Xin-Yi Zhou, Yi-Ping Lu, Rong Chen, Chin-Ho Zhang, Meng-Han Cheng, Yung-Yi Morris-Natschke, Susan L. Lee, Kuo-Hsiung Wang, Yun-Song |
| author_facet | Yang, Jing-Hua Wang, Xin-Yi Zhou, Yi-Ping Lu, Rong Chen, Chin-Ho Zhang, Meng-Han Cheng, Yung-Yi Morris-Natschke, Susan L. Lee, Kuo-Hsiung Wang, Yun-Song |
| author_sort | Yang, Jing-Hua |
| collection | PubMed |
| description | Two new carbazole alkaloids (1,2) and six known carbazole alkaloids (3–8) were isolated from Clausena anisum-olens. Their structures were elucidated based on extensive spectroscopic analysis. All isolated compounds (1–8) were evaluated for their anti-HIV effects on virus replication in MT-4 lymphocytes infected by HIV-1(NL4-3) Nanoluc-sec virus, and new carbazole alkaloid 1 exhibited anti-HIV activity with an EC(50) value of 2.4 μg/mL and SI of 7.1. |
| format | Online Article Text |
| id | pubmed-6983056 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2019 |
| publisher | MDPI |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-69830562020-02-06 Carbazole Alkaloids from Clausena anisum-olens: Isolation, Characterization, and Anti-HIV Evaluation Yang, Jing-Hua Wang, Xin-Yi Zhou, Yi-Ping Lu, Rong Chen, Chin-Ho Zhang, Meng-Han Cheng, Yung-Yi Morris-Natschke, Susan L. Lee, Kuo-Hsiung Wang, Yun-Song Molecules Article Two new carbazole alkaloids (1,2) and six known carbazole alkaloids (3–8) were isolated from Clausena anisum-olens. Their structures were elucidated based on extensive spectroscopic analysis. All isolated compounds (1–8) were evaluated for their anti-HIV effects on virus replication in MT-4 lymphocytes infected by HIV-1(NL4-3) Nanoluc-sec virus, and new carbazole alkaloid 1 exhibited anti-HIV activity with an EC(50) value of 2.4 μg/mL and SI of 7.1. MDPI 2019-12-26 /pmc/articles/PMC6983056/ /pubmed/31888067 http://dx.doi.org/10.3390/molecules25010099 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
| spellingShingle | Article Yang, Jing-Hua Wang, Xin-Yi Zhou, Yi-Ping Lu, Rong Chen, Chin-Ho Zhang, Meng-Han Cheng, Yung-Yi Morris-Natschke, Susan L. Lee, Kuo-Hsiung Wang, Yun-Song Carbazole Alkaloids from Clausena anisum-olens: Isolation, Characterization, and Anti-HIV Evaluation |
| title | Carbazole Alkaloids from Clausena anisum-olens: Isolation, Characterization, and Anti-HIV Evaluation |
| title_full | Carbazole Alkaloids from Clausena anisum-olens: Isolation, Characterization, and Anti-HIV Evaluation |
| title_fullStr | Carbazole Alkaloids from Clausena anisum-olens: Isolation, Characterization, and Anti-HIV Evaluation |
| title_full_unstemmed | Carbazole Alkaloids from Clausena anisum-olens: Isolation, Characterization, and Anti-HIV Evaluation |
| title_short | Carbazole Alkaloids from Clausena anisum-olens: Isolation, Characterization, and Anti-HIV Evaluation |
| title_sort | carbazole alkaloids from clausena anisum-olens: isolation, characterization, and anti-hiv evaluation |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6983056/ https://www.ncbi.nlm.nih.gov/pubmed/31888067 http://dx.doi.org/10.3390/molecules25010099 |
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