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Biologically Active Echinulin-Related Indolediketopiperazines from the Marine Sediment-Derived Fungus Aspergillus niveoglaucus
Seven known echinulin-related indolediketopiperazine alkaloids (1–7) were isolated from the Vietnamese sediment-derived fungus Aspergillus niveoglaucus. Using chiral HPLC, the enantiomers of cryptoechinuline B (1) were isolated as individual compounds for the first time. (+)-Cryptoechinuline B (1a)...
| Autores principales: | , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6983058/ https://www.ncbi.nlm.nih.gov/pubmed/31878044 http://dx.doi.org/10.3390/molecules25010061 |
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| author | Smetanina, Olga F. Yurchenko, Anton N. Girich (Ivanets), Elena V. Trinh, Phan Thi Hoai Antonov, Alexander S. Dyshlovoy, Sergey A. von Amsberg, Gunhild Kim, Natalya Y. Chingizova, Ekaterina A. Pislyagin, Evgeny A. Menchinskaya, Ekaterina S. Yurchenko, Ekaterina A. Van, Tran Thi Thanh Afiyatullov, Shamil S. |
| author_facet | Smetanina, Olga F. Yurchenko, Anton N. Girich (Ivanets), Elena V. Trinh, Phan Thi Hoai Antonov, Alexander S. Dyshlovoy, Sergey A. von Amsberg, Gunhild Kim, Natalya Y. Chingizova, Ekaterina A. Pislyagin, Evgeny A. Menchinskaya, Ekaterina S. Yurchenko, Ekaterina A. Van, Tran Thi Thanh Afiyatullov, Shamil S. |
| author_sort | Smetanina, Olga F. |
| collection | PubMed |
| description | Seven known echinulin-related indolediketopiperazine alkaloids (1–7) were isolated from the Vietnamese sediment-derived fungus Aspergillus niveoglaucus. Using chiral HPLC, the enantiomers of cryptoechinuline B (1) were isolated as individual compounds for the first time. (+)-Cryptoechinuline B (1a) exhibited neuroprotective activity in 6-OHDA-, paraquat-, and rotenone-induced in vitro models of Parkinson’s disease. (−)-Cryptoechinuline B (1b) and neoechinulin C (5) protected the neuronal cells against paraquat-induced damage in a Parkinson’s disease model. Neoechinulin B (4) exhibited cytoprotective activity in a rotenone-induced model, and neoechinulin (7) showed activity in the 6-OHDA-induced model. |
| format | Online Article Text |
| id | pubmed-6983058 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2019 |
| publisher | MDPI |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-69830582020-02-06 Biologically Active Echinulin-Related Indolediketopiperazines from the Marine Sediment-Derived Fungus Aspergillus niveoglaucus Smetanina, Olga F. Yurchenko, Anton N. Girich (Ivanets), Elena V. Trinh, Phan Thi Hoai Antonov, Alexander S. Dyshlovoy, Sergey A. von Amsberg, Gunhild Kim, Natalya Y. Chingizova, Ekaterina A. Pislyagin, Evgeny A. Menchinskaya, Ekaterina S. Yurchenko, Ekaterina A. Van, Tran Thi Thanh Afiyatullov, Shamil S. Molecules Article Seven known echinulin-related indolediketopiperazine alkaloids (1–7) were isolated from the Vietnamese sediment-derived fungus Aspergillus niveoglaucus. Using chiral HPLC, the enantiomers of cryptoechinuline B (1) were isolated as individual compounds for the first time. (+)-Cryptoechinuline B (1a) exhibited neuroprotective activity in 6-OHDA-, paraquat-, and rotenone-induced in vitro models of Parkinson’s disease. (−)-Cryptoechinuline B (1b) and neoechinulin C (5) protected the neuronal cells against paraquat-induced damage in a Parkinson’s disease model. Neoechinulin B (4) exhibited cytoprotective activity in a rotenone-induced model, and neoechinulin (7) showed activity in the 6-OHDA-induced model. MDPI 2019-12-23 /pmc/articles/PMC6983058/ /pubmed/31878044 http://dx.doi.org/10.3390/molecules25010061 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
| spellingShingle | Article Smetanina, Olga F. Yurchenko, Anton N. Girich (Ivanets), Elena V. Trinh, Phan Thi Hoai Antonov, Alexander S. Dyshlovoy, Sergey A. von Amsberg, Gunhild Kim, Natalya Y. Chingizova, Ekaterina A. Pislyagin, Evgeny A. Menchinskaya, Ekaterina S. Yurchenko, Ekaterina A. Van, Tran Thi Thanh Afiyatullov, Shamil S. Biologically Active Echinulin-Related Indolediketopiperazines from the Marine Sediment-Derived Fungus Aspergillus niveoglaucus |
| title | Biologically Active Echinulin-Related Indolediketopiperazines from the Marine Sediment-Derived Fungus Aspergillus niveoglaucus |
| title_full | Biologically Active Echinulin-Related Indolediketopiperazines from the Marine Sediment-Derived Fungus Aspergillus niveoglaucus |
| title_fullStr | Biologically Active Echinulin-Related Indolediketopiperazines from the Marine Sediment-Derived Fungus Aspergillus niveoglaucus |
| title_full_unstemmed | Biologically Active Echinulin-Related Indolediketopiperazines from the Marine Sediment-Derived Fungus Aspergillus niveoglaucus |
| title_short | Biologically Active Echinulin-Related Indolediketopiperazines from the Marine Sediment-Derived Fungus Aspergillus niveoglaucus |
| title_sort | biologically active echinulin-related indolediketopiperazines from the marine sediment-derived fungus aspergillus niveoglaucus |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6983058/ https://www.ncbi.nlm.nih.gov/pubmed/31878044 http://dx.doi.org/10.3390/molecules25010061 |
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