Identifying Ortholog Selective Fragment Molecules for Bacterial Glutaredoxins by NMR and Affinity Enhancement by Modification with an Acrylamide Warhead

Illustrated here is the development of a new class of antibiotic lead molecules targeted at Pseudomonas aeruginosa glutaredoxin (PaGRX). This lead was produced to (a) circumvent efflux-mediated resistance mechanisms via covalent inhibition while (b) taking advantage of species selectivity to target...

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Detalles Bibliográficos
Autores principales: Khattri, Ram B., Morris, Daniel L., Bilinovich, Stephanie M., Manandhar, Erendra, Napper, Kahlilah R., Sweet, Jacob W., Modarelli, David A., Leeper, Thomas C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6983068/
https://www.ncbi.nlm.nih.gov/pubmed/31905878
http://dx.doi.org/10.3390/molecules25010147

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