Activity Dependence of a Novel Lectin Family on Structure and Carbohydrate-Binding Properties

A GalNAc/Gal-specific lectins named CGL and MTL were isolated and characterized from the edible mussels Crenomytilus grayanus and Mytilus trossulus. Amino acid sequence analysis of these lectins showed that they, together with another lectin MytiLec-1, formed a novel lectin family, adopting β-trefoi...

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Autores principales: Chikalovets, Irina, Filshtein, Alina, Molchanova, Valentina, Mizgina, Tatyana, Lukyanov, Pavel, Nedashkovskaya, Olga, Hua, Kuo-Feng, Chernikov, Oleg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6983116/
https://www.ncbi.nlm.nih.gov/pubmed/31905927
http://dx.doi.org/10.3390/molecules25010150
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author Chikalovets, Irina
Filshtein, Alina
Molchanova, Valentina
Mizgina, Tatyana
Lukyanov, Pavel
Nedashkovskaya, Olga
Hua, Kuo-Feng
Chernikov, Oleg
author_facet Chikalovets, Irina
Filshtein, Alina
Molchanova, Valentina
Mizgina, Tatyana
Lukyanov, Pavel
Nedashkovskaya, Olga
Hua, Kuo-Feng
Chernikov, Oleg
author_sort Chikalovets, Irina
collection PubMed
description A GalNAc/Gal-specific lectins named CGL and MTL were isolated and characterized from the edible mussels Crenomytilus grayanus and Mytilus trossulus. Amino acid sequence analysis of these lectins showed that they, together with another lectin MytiLec-1, formed a novel lectin family, adopting β-trefoil fold. In this mini review we discuss the structure, oligomerization, and carbohydrate-binding properties of a novel lectin family. We describe also the antibacterial, antifungal, and antiproliferative activities of these lectins and report about dependence of activities on molecular properties. Summarizing, CGL, MTL, and MytiLec-1 could be involved in the immunity in mollusks and may become a basis for the elaboration of new diagnostic tools or treatments for a variety of cancers.
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spelling pubmed-69831162020-02-06 Activity Dependence of a Novel Lectin Family on Structure and Carbohydrate-Binding Properties Chikalovets, Irina Filshtein, Alina Molchanova, Valentina Mizgina, Tatyana Lukyanov, Pavel Nedashkovskaya, Olga Hua, Kuo-Feng Chernikov, Oleg Molecules Review A GalNAc/Gal-specific lectins named CGL and MTL were isolated and characterized from the edible mussels Crenomytilus grayanus and Mytilus trossulus. Amino acid sequence analysis of these lectins showed that they, together with another lectin MytiLec-1, formed a novel lectin family, adopting β-trefoil fold. In this mini review we discuss the structure, oligomerization, and carbohydrate-binding properties of a novel lectin family. We describe also the antibacterial, antifungal, and antiproliferative activities of these lectins and report about dependence of activities on molecular properties. Summarizing, CGL, MTL, and MytiLec-1 could be involved in the immunity in mollusks and may become a basis for the elaboration of new diagnostic tools or treatments for a variety of cancers. MDPI 2019-12-30 /pmc/articles/PMC6983116/ /pubmed/31905927 http://dx.doi.org/10.3390/molecules25010150 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Chikalovets, Irina
Filshtein, Alina
Molchanova, Valentina
Mizgina, Tatyana
Lukyanov, Pavel
Nedashkovskaya, Olga
Hua, Kuo-Feng
Chernikov, Oleg
Activity Dependence of a Novel Lectin Family on Structure and Carbohydrate-Binding Properties
title Activity Dependence of a Novel Lectin Family on Structure and Carbohydrate-Binding Properties
title_full Activity Dependence of a Novel Lectin Family on Structure and Carbohydrate-Binding Properties
title_fullStr Activity Dependence of a Novel Lectin Family on Structure and Carbohydrate-Binding Properties
title_full_unstemmed Activity Dependence of a Novel Lectin Family on Structure and Carbohydrate-Binding Properties
title_short Activity Dependence of a Novel Lectin Family on Structure and Carbohydrate-Binding Properties
title_sort activity dependence of a novel lectin family on structure and carbohydrate-binding properties
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6983116/
https://www.ncbi.nlm.nih.gov/pubmed/31905927
http://dx.doi.org/10.3390/molecules25010150
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