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Electrochemical Preparation of Synergistic Nanoantimicrobials

The rapid spreading of resistance among common bacterial pathogens towards the misused antibiotics/disinfectant agents has drawn much attention worldwide to bacterial infections. In light of this, the present work aimed at the realization of core–shell nanoparticles possessing remarkable antimicrobi...

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Detalles Bibliográficos
Autores principales: Sportelli, Maria Chiara, Longano, Daniela, Bonerba, Elisabetta, Tantillo, Giuseppina, Torsi, Luisa, Sabbatini, Luigia, Cioffi, Nicola, Ditaranto, Nicoletta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6983245/
https://www.ncbi.nlm.nih.gov/pubmed/31877834
http://dx.doi.org/10.3390/molecules25010049
Descripción
Sumario:The rapid spreading of resistance among common bacterial pathogens towards the misused antibiotics/disinfectant agents has drawn much attention worldwide to bacterial infections. In light of this, the present work aimed at the realization of core–shell nanoparticles possessing remarkable antimicrobial properties thanks to the synergistic action of the metal core and the disinfectant shell. Copper nanoparticles stabilized by benzalkonium chloride were prepared, characterized, and implemented in poly-vinyl-methyl ketone to obtain nanoantimicrobial composite coatings. Bioactivity tests are reported, proving the excellent disinfectant properties of the proposed nanomaterials, as compared to one of the well-known and strongest silver-based nanoantimicrobials. Applications are also briefly described.