Cargando…

Electrochemical Preparation of Synergistic Nanoantimicrobials

The rapid spreading of resistance among common bacterial pathogens towards the misused antibiotics/disinfectant agents has drawn much attention worldwide to bacterial infections. In light of this, the present work aimed at the realization of core–shell nanoparticles possessing remarkable antimicrobi...

Descripción completa

Detalles Bibliográficos
Autores principales: Sportelli, Maria Chiara, Longano, Daniela, Bonerba, Elisabetta, Tantillo, Giuseppina, Torsi, Luisa, Sabbatini, Luigia, Cioffi, Nicola, Ditaranto, Nicoletta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6983245/
https://www.ncbi.nlm.nih.gov/pubmed/31877834
http://dx.doi.org/10.3390/molecules25010049
_version_ 1783491475934281728
author Sportelli, Maria Chiara
Longano, Daniela
Bonerba, Elisabetta
Tantillo, Giuseppina
Torsi, Luisa
Sabbatini, Luigia
Cioffi, Nicola
Ditaranto, Nicoletta
author_facet Sportelli, Maria Chiara
Longano, Daniela
Bonerba, Elisabetta
Tantillo, Giuseppina
Torsi, Luisa
Sabbatini, Luigia
Cioffi, Nicola
Ditaranto, Nicoletta
author_sort Sportelli, Maria Chiara
collection PubMed
description The rapid spreading of resistance among common bacterial pathogens towards the misused antibiotics/disinfectant agents has drawn much attention worldwide to bacterial infections. In light of this, the present work aimed at the realization of core–shell nanoparticles possessing remarkable antimicrobial properties thanks to the synergistic action of the metal core and the disinfectant shell. Copper nanoparticles stabilized by benzalkonium chloride were prepared, characterized, and implemented in poly-vinyl-methyl ketone to obtain nanoantimicrobial composite coatings. Bioactivity tests are reported, proving the excellent disinfectant properties of the proposed nanomaterials, as compared to one of the well-known and strongest silver-based nanoantimicrobials. Applications are also briefly described.
format Online
Article
Text
id pubmed-6983245
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-69832452020-02-06 Electrochemical Preparation of Synergistic Nanoantimicrobials Sportelli, Maria Chiara Longano, Daniela Bonerba, Elisabetta Tantillo, Giuseppina Torsi, Luisa Sabbatini, Luigia Cioffi, Nicola Ditaranto, Nicoletta Molecules Article The rapid spreading of resistance among common bacterial pathogens towards the misused antibiotics/disinfectant agents has drawn much attention worldwide to bacterial infections. In light of this, the present work aimed at the realization of core–shell nanoparticles possessing remarkable antimicrobial properties thanks to the synergistic action of the metal core and the disinfectant shell. Copper nanoparticles stabilized by benzalkonium chloride were prepared, characterized, and implemented in poly-vinyl-methyl ketone to obtain nanoantimicrobial composite coatings. Bioactivity tests are reported, proving the excellent disinfectant properties of the proposed nanomaterials, as compared to one of the well-known and strongest silver-based nanoantimicrobials. Applications are also briefly described. MDPI 2019-12-22 /pmc/articles/PMC6983245/ /pubmed/31877834 http://dx.doi.org/10.3390/molecules25010049 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Sportelli, Maria Chiara
Longano, Daniela
Bonerba, Elisabetta
Tantillo, Giuseppina
Torsi, Luisa
Sabbatini, Luigia
Cioffi, Nicola
Ditaranto, Nicoletta
Electrochemical Preparation of Synergistic Nanoantimicrobials
title Electrochemical Preparation of Synergistic Nanoantimicrobials
title_full Electrochemical Preparation of Synergistic Nanoantimicrobials
title_fullStr Electrochemical Preparation of Synergistic Nanoantimicrobials
title_full_unstemmed Electrochemical Preparation of Synergistic Nanoantimicrobials
title_short Electrochemical Preparation of Synergistic Nanoantimicrobials
title_sort electrochemical preparation of synergistic nanoantimicrobials
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6983245/
https://www.ncbi.nlm.nih.gov/pubmed/31877834
http://dx.doi.org/10.3390/molecules25010049
work_keys_str_mv AT sportellimariachiara electrochemicalpreparationofsynergisticnanoantimicrobials
AT longanodaniela electrochemicalpreparationofsynergisticnanoantimicrobials
AT bonerbaelisabetta electrochemicalpreparationofsynergisticnanoantimicrobials
AT tantillogiuseppina electrochemicalpreparationofsynergisticnanoantimicrobials
AT torsiluisa electrochemicalpreparationofsynergisticnanoantimicrobials
AT sabbatiniluigia electrochemicalpreparationofsynergisticnanoantimicrobials
AT cioffinicola electrochemicalpreparationofsynergisticnanoantimicrobials
AT ditarantonicoletta electrochemicalpreparationofsynergisticnanoantimicrobials