Large-scale contractions of Friedreich’s ataxia GAA repeats in yeast occur during DNA replication due to their triplex-forming ability

Friedreich’s ataxia (FRDA) is a human hereditary disease caused by the presence of expanded (GAA)(n) repeats in the first intron of the FXN gene [V. Campuzano et al., Science 271, 1423–1427 (1996)]. In somatic tissues of FRDA patients, (GAA)(n) repeat tracts are highly unstable, with contractions mo...

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Detalles Bibliográficos
Autores principales: Khristich, Alexandra N., Armenia, Jillian F., Matera, Robert M., Kolchinski, Anna A., Mirkin, Sergei M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6983365/
https://www.ncbi.nlm.nih.gov/pubmed/31911468
http://dx.doi.org/10.1073/pnas.1913416117

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