Expansion, in vivo–ex vivo cycling, and genetic manipulation of primary human hepatocytes

Primary human hepatocytes (PHHs) are an essential tool for modeling drug metabolism and liver disease. However, variable plating efficiencies, short lifespan in culture, and resistance to genetic manipulation have limited their use. Here, we show that the pyrrolizidine alkaloid retrorsine improves P...

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Detalles Bibliográficos
Autores principales: Michailidis, Eleftherios, Vercauteren, Koen, Mancio-Silva, Liliana, Andrus, Linda, Jahan, Cyprien, Ricardo-Lax, Inna, Zou, Chenhui, Kabbani, Mohammad, Park, Paul, Quirk, Corrine, Pyrgaki, Christina, Razooky, Brandon, Verhoye, Lieven, Zoluthkin, Irene, Lu, Wei-Yu, Forbes, Stuart J., Chiriboga, Luis, Theise, Neil D., Herzog, Roland W., Suemizu, Hiroshi, Schneider, William M., Shlomai, Amir, Meuleman, Philip, Bhatia, Sangeeta N., Rice, Charles M., de Jong, Ype P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6983380/
https://www.ncbi.nlm.nih.gov/pubmed/31915293
http://dx.doi.org/10.1073/pnas.1919035117

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