Microparticle-associated tissue factor activity in dogs with disseminated intravascular coagulation

Microparticle (MP)-associated tissue factor (TF) activity in plasma might play a role in human disseminated intravascular coagulation (DIC). The aim of this study was to compare MP-TF activity between non-DIC and DIC groups. Ten clinically healthy beagles and 26 diseased dogs were enrolled. The prop...

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Autores principales: KOBAYASHI, Kosuke, BABA, Kenji, IGASE, Masaya, MIYAMA, Takako Shimokawa, KAMBAYASHI, Satoshi, OKUDA, Masaru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Veterinary Science 2019
Materias:
Internal Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6983662/
https://www.ncbi.nlm.nih.gov/pubmed/31787663
http://dx.doi.org/10.1292/jvms.19-0553
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author KOBAYASHI, Kosuke
BABA, Kenji
IGASE, Masaya
MIYAMA, Takako Shimokawa
KAMBAYASHI, Satoshi
OKUDA, Masaru
author_facet KOBAYASHI, Kosuke
BABA, Kenji
IGASE, Masaya
MIYAMA, Takako Shimokawa
KAMBAYASHI, Satoshi
OKUDA, Masaru
author_sort KOBAYASHI, Kosuke
collection PubMed
description Microparticle (MP)-associated tissue factor (TF) activity in plasma might play a role in human disseminated intravascular coagulation (DIC). The aim of this study was to compare MP-TF activity between non-DIC and DIC groups. Ten clinically healthy beagles and 26 diseased dogs were enrolled. The proportion of dogs with increased MP-TF activity was significantly higher in the DIC group than the non-DIC group (P=0.014). MP-TF activity in the DIC group was significantly higher than the non-DIC group (P=0.021). MP-TF activity positively correlated with plasma D-dimer concentration (r=0.42, P=0.034). Moreover, MP-TF activity was decreased by the time of recovery in some dogs with DIC. Larger prospective studies are warranted to assess its value as a diagnostic and prognostic biomarker in DIC.
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spelling pubmed-69836622020-01-30 Microparticle-associated tissue factor activity in dogs with disseminated intravascular coagulation KOBAYASHI, Kosuke BABA, Kenji IGASE, Masaya MIYAMA, Takako Shimokawa KAMBAYASHI, Satoshi OKUDA, Masaru J Vet Med Sci Internal Medicine Microparticle (MP)-associated tissue factor (TF) activity in plasma might play a role in human disseminated intravascular coagulation (DIC). The aim of this study was to compare MP-TF activity between non-DIC and DIC groups. Ten clinically healthy beagles and 26 diseased dogs were enrolled. The proportion of dogs with increased MP-TF activity was significantly higher in the DIC group than the non-DIC group (P=0.014). MP-TF activity in the DIC group was significantly higher than the non-DIC group (P=0.021). MP-TF activity positively correlated with plasma D-dimer concentration (r=0.42, P=0.034). Moreover, MP-TF activity was decreased by the time of recovery in some dogs with DIC. Larger prospective studies are warranted to assess its value as a diagnostic and prognostic biomarker in DIC. The Japanese Society of Veterinary Science 2019-12-02 2020-01 /pmc/articles/PMC6983662/ /pubmed/31787663 http://dx.doi.org/10.1292/jvms.19-0553 Text en ©2020 The Japanese Society of Veterinary Science This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Internal Medicine
KOBAYASHI, Kosuke
BABA, Kenji
IGASE, Masaya
MIYAMA, Takako Shimokawa
KAMBAYASHI, Satoshi
OKUDA, Masaru
Microparticle-associated tissue factor activity in dogs with disseminated intravascular coagulation
title Microparticle-associated tissue factor activity in dogs with disseminated intravascular coagulation
title_full Microparticle-associated tissue factor activity in dogs with disseminated intravascular coagulation
title_fullStr Microparticle-associated tissue factor activity in dogs with disseminated intravascular coagulation
title_full_unstemmed Microparticle-associated tissue factor activity in dogs with disseminated intravascular coagulation
title_short Microparticle-associated tissue factor activity in dogs with disseminated intravascular coagulation
title_sort microparticle-associated tissue factor activity in dogs with disseminated intravascular coagulation
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6983662/
https://www.ncbi.nlm.nih.gov/pubmed/31787663
http://dx.doi.org/10.1292/jvms.19-0553
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