Biochemical and structural analyses reveal that the tumor suppressor neurofibromin (NF1) forms a high-affinity dimer

Neurofibromin is a tumor suppressor encoded by the NF1 gene, which is mutated in Rasopathy disease neurofibromatosis type I. Defects in NF1 lead to aberrant signaling through the RAS–mitogen-activated protein kinase pathway due to disruption of the neurofibromin GTPase-activating function on RAS fam...

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Detalles Bibliográficos
Autores principales: Sherekar, Mukul, Han, Sae-Won, Ghirlando, Rodolfo, Messing, Simon, Drew, Matthew, Rabara, Dana, Waybright, Timothy, Juneja, Puneet, O'Neill, Hugh, Stanley, Christopher B., Bhowmik, Debsindhu, Ramanathan, Arvind, Subramaniam, Sriram, Nissley, Dwight V., Gillette, William, McCormick, Frank, Esposito, Dominic
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2020
Materias:
Protein Structure and Folding
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6983858/
https://www.ncbi.nlm.nih.gov/pubmed/31836666
http://dx.doi.org/10.1074/jbc.RA119.010934

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