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Supplementation with cod protein hydrolysate in older adults: a dose range cross-over study

A large proportion of older adults are affected by impaired glucose metabolism. Previous studies with fish protein have reported improved glucose regulation in healthy adults, but the evidence in older adults is limited. Therefore, we wanted to assess the effect of increasing doses of a cod protein...

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Autores principales: Jensen, Caroline, Dale, Hanna F., Hausken, Trygve, Lied, Einar, Hatlebakk, Jan G., Brønstad, Ingeborg, Lied, Gülen A., Hoff, Dag Arne L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cambridge University Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6984005/
https://www.ncbi.nlm.nih.gov/pubmed/32042407
http://dx.doi.org/10.1017/jns.2019.37
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author Jensen, Caroline
Dale, Hanna F.
Hausken, Trygve
Lied, Einar
Hatlebakk, Jan G.
Brønstad, Ingeborg
Lied, Gülen A.
Hoff, Dag Arne L.
author_facet Jensen, Caroline
Dale, Hanna F.
Hausken, Trygve
Lied, Einar
Hatlebakk, Jan G.
Brønstad, Ingeborg
Lied, Gülen A.
Hoff, Dag Arne L.
author_sort Jensen, Caroline
collection PubMed
description A large proportion of older adults are affected by impaired glucose metabolism. Previous studies with fish protein have reported improved glucose regulation in healthy adults, but the evidence in older adults is limited. Therefore, we wanted to assess the effect of increasing doses of a cod protein hydrolysate (CPH) on postprandial glucose metabolism in older adults. The study was a double-blind cross-over trial. Participants received four different doses (10, 20, 30 or 40 mg/kg body weight (BW)) of CPH daily for 1 week with 1-week washout periods in between. The primary outcome was postprandial response in glucose metabolism, measured by samples of serum glucose and insulin in 20 min intervals for 120 min. The secondary outcome was postprandial response in plasma glucagon-like peptide 1 (GLP-1). Thirty-one subjects aged 60–78 years were included in the study. In a mixed-model statistical analysis, no differences in estimated maximum value of glucose, insulin or GLP-1 were observed when comparing the lowest dose of CPH (10 mg/kg BW) with the higher doses (20, 30 or 40 mg/kg BW). The estimated maximum value of glucose was on average 0·28 mmol/l lower when the participants were given 40 mg/kg BW CPH compared with 10 mg/kg BW (P = 0·13). The estimated maximum value of insulin was on average 5·14 mIU/l lower with 40 mg/kg BW of CPH compared with 10 mg/kg BW (P = 0·20). Our findings suggest that serum glucose and insulin levels tend to decrease with increasing amounts of CPH. Due to preliminary findings, the results require further investigation.
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spelling pubmed-69840052020-02-10 Supplementation with cod protein hydrolysate in older adults: a dose range cross-over study Jensen, Caroline Dale, Hanna F. Hausken, Trygve Lied, Einar Hatlebakk, Jan G. Brønstad, Ingeborg Lied, Gülen A. Hoff, Dag Arne L. J Nutr Sci Research Article A large proportion of older adults are affected by impaired glucose metabolism. Previous studies with fish protein have reported improved glucose regulation in healthy adults, but the evidence in older adults is limited. Therefore, we wanted to assess the effect of increasing doses of a cod protein hydrolysate (CPH) on postprandial glucose metabolism in older adults. The study was a double-blind cross-over trial. Participants received four different doses (10, 20, 30 or 40 mg/kg body weight (BW)) of CPH daily for 1 week with 1-week washout periods in between. The primary outcome was postprandial response in glucose metabolism, measured by samples of serum glucose and insulin in 20 min intervals for 120 min. The secondary outcome was postprandial response in plasma glucagon-like peptide 1 (GLP-1). Thirty-one subjects aged 60–78 years were included in the study. In a mixed-model statistical analysis, no differences in estimated maximum value of glucose, insulin or GLP-1 were observed when comparing the lowest dose of CPH (10 mg/kg BW) with the higher doses (20, 30 or 40 mg/kg BW). The estimated maximum value of glucose was on average 0·28 mmol/l lower when the participants were given 40 mg/kg BW CPH compared with 10 mg/kg BW (P = 0·13). The estimated maximum value of insulin was on average 5·14 mIU/l lower with 40 mg/kg BW of CPH compared with 10 mg/kg BW (P = 0·20). Our findings suggest that serum glucose and insulin levels tend to decrease with increasing amounts of CPH. Due to preliminary findings, the results require further investigation. Cambridge University Press 2019-12-04 /pmc/articles/PMC6984005/ /pubmed/32042407 http://dx.doi.org/10.1017/jns.2019.37 Text en © The Author(s) 2019 http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Jensen, Caroline
Dale, Hanna F.
Hausken, Trygve
Lied, Einar
Hatlebakk, Jan G.
Brønstad, Ingeborg
Lied, Gülen A.
Hoff, Dag Arne L.
Supplementation with cod protein hydrolysate in older adults: a dose range cross-over study
title Supplementation with cod protein hydrolysate in older adults: a dose range cross-over study
title_full Supplementation with cod protein hydrolysate in older adults: a dose range cross-over study
title_fullStr Supplementation with cod protein hydrolysate in older adults: a dose range cross-over study
title_full_unstemmed Supplementation with cod protein hydrolysate in older adults: a dose range cross-over study
title_short Supplementation with cod protein hydrolysate in older adults: a dose range cross-over study
title_sort supplementation with cod protein hydrolysate in older adults: a dose range cross-over study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6984005/
https://www.ncbi.nlm.nih.gov/pubmed/32042407
http://dx.doi.org/10.1017/jns.2019.37
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