A hydroxamic-acid-containing nucleoside inhibits DNA repair nuclease SNM1A

Nine modified nucleosides, incorporating zinc-binding pharmacophores, have been synthesised and evaluated as inhibitors of the DNA repair nuclease SNM1A. The series included oxyamides, hydroxamic acids, hydroxamates, a hydrazide, a squarate ester and a squaramide. A hydroxamic acid-derived nucleosid...

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Detalles Bibliográficos
Autores principales: Doherty, William, Dürr, Eva-Maria, Baddock, Hannah T., Lee, Sook Y., McHugh, Peter J., Brown, Tom, Senge, Mathias O., Scanlan, Eoin M., McGouran, Joanna F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6984127/
https://www.ncbi.nlm.nih.gov/pubmed/31380542
http://dx.doi.org/10.1039/c9ob01133a
Descripción
Sumario:Nine modified nucleosides, incorporating zinc-binding pharmacophores, have been synthesised and evaluated as inhibitors of the DNA repair nuclease SNM1A. The series included oxyamides, hydroxamic acids, hydroxamates, a hydrazide, a squarate ester and a squaramide. A hydroxamic acid-derived nucleoside inhibited the enzyme, offering a novel approach for potential therapeutic development through the use of rationally designed nucleoside derived inhibitors.

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