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A hydroxamic-acid-containing nucleoside inhibits DNA repair nuclease SNM1A
Nine modified nucleosides, incorporating zinc-binding pharmacophores, have been synthesised and evaluated as inhibitors of the DNA repair nuclease SNM1A. The series included oxyamides, hydroxamic acids, hydroxamates, a hydrazide, a squarate ester and a squaramide. A hydroxamic acid-derived nucleosid...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Royal Society of Chemistry
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6984127/ https://www.ncbi.nlm.nih.gov/pubmed/31380542 http://dx.doi.org/10.1039/c9ob01133a |
| _version_ | 1783491603947585536 |
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| author | Doherty, William Dürr, Eva-Maria Baddock, Hannah T. Lee, Sook Y. McHugh, Peter J. Brown, Tom Senge, Mathias O. Scanlan, Eoin M. McGouran, Joanna F. |
| author_facet | Doherty, William Dürr, Eva-Maria Baddock, Hannah T. Lee, Sook Y. McHugh, Peter J. Brown, Tom Senge, Mathias O. Scanlan, Eoin M. McGouran, Joanna F. |
| author_sort | Doherty, William |
| collection | PubMed |
| description | Nine modified nucleosides, incorporating zinc-binding pharmacophores, have been synthesised and evaluated as inhibitors of the DNA repair nuclease SNM1A. The series included oxyamides, hydroxamic acids, hydroxamates, a hydrazide, a squarate ester and a squaramide. A hydroxamic acid-derived nucleoside inhibited the enzyme, offering a novel approach for potential therapeutic development through the use of rationally designed nucleoside derived inhibitors. |
| format | Online Article Text |
| id | pubmed-6984127 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2019 |
| publisher | Royal Society of Chemistry |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-69841272020-03-04 A hydroxamic-acid-containing nucleoside inhibits DNA repair nuclease SNM1A Doherty, William Dürr, Eva-Maria Baddock, Hannah T. Lee, Sook Y. McHugh, Peter J. Brown, Tom Senge, Mathias O. Scanlan, Eoin M. McGouran, Joanna F. Org Biomol Chem Chemistry Nine modified nucleosides, incorporating zinc-binding pharmacophores, have been synthesised and evaluated as inhibitors of the DNA repair nuclease SNM1A. The series included oxyamides, hydroxamic acids, hydroxamates, a hydrazide, a squarate ester and a squaramide. A hydroxamic acid-derived nucleoside inhibited the enzyme, offering a novel approach for potential therapeutic development through the use of rationally designed nucleoside derived inhibitors. Royal Society of Chemistry 2019-09-21 2019-08-05 /pmc/articles/PMC6984127/ /pubmed/31380542 http://dx.doi.org/10.1039/c9ob01133a Text en This journal is © The Royal Society of Chemistry 2019 http://creativecommons.org/licenses/by/3.0/ This article is freely available. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence (CC BY 3.0) |
| spellingShingle | Chemistry Doherty, William Dürr, Eva-Maria Baddock, Hannah T. Lee, Sook Y. McHugh, Peter J. Brown, Tom Senge, Mathias O. Scanlan, Eoin M. McGouran, Joanna F. A hydroxamic-acid-containing nucleoside inhibits DNA repair nuclease SNM1A |
| title | A hydroxamic-acid-containing nucleoside inhibits DNA repair nuclease SNM1A
|
| title_full | A hydroxamic-acid-containing nucleoside inhibits DNA repair nuclease SNM1A
|
| title_fullStr | A hydroxamic-acid-containing nucleoside inhibits DNA repair nuclease SNM1A
|
| title_full_unstemmed | A hydroxamic-acid-containing nucleoside inhibits DNA repair nuclease SNM1A
|
| title_short | A hydroxamic-acid-containing nucleoside inhibits DNA repair nuclease SNM1A
|
| title_sort | hydroxamic-acid-containing nucleoside inhibits dna repair nuclease snm1a |
| topic | Chemistry |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6984127/ https://www.ncbi.nlm.nih.gov/pubmed/31380542 http://dx.doi.org/10.1039/c9ob01133a |
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