Two Cases of Very-Late-Onset Neuromyelitis Optica Spectrum Disorder (NMOSD) in Patients over the Age of 80

We report two cases of very-late-onset neuromyelitis optica spectrum disorder (NMOSD) in patients over the age of 80 with transverse myelopathy as the initial manifestation. In both cases, the patients presented with paraplegia and sensory, bladder, and rectal disturbances. Thoracic magnetic resonan...

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Autores principales: Fujiwara, Shunya, Manabe, Yasuhiro, Morihara, Ryuta, Yunoki, Taijun, Kono, Syoichiro, Narai, Hisashi, Abe, Koji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2020
Materias:
Single Case – General Neurology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6984149/
https://www.ncbi.nlm.nih.gov/pubmed/32009931
http://dx.doi.org/10.1159/000505231
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author Fujiwara, Shunya
Manabe, Yasuhiro
Morihara, Ryuta
Yunoki, Taijun
Kono, Syoichiro
Narai, Hisashi
Abe, Koji
author_facet Fujiwara, Shunya
Manabe, Yasuhiro
Morihara, Ryuta
Yunoki, Taijun
Kono, Syoichiro
Narai, Hisashi
Abe, Koji
author_sort Fujiwara, Shunya
collection PubMed
description We report two cases of very-late-onset neuromyelitis optica spectrum disorder (NMOSD) in patients over the age of 80 with transverse myelopathy as the initial manifestation. In both cases, the patients presented with paraplegia and sensory, bladder, and rectal disturbances. Thoracic magnetic resonance imaging showed longitudinal high-intensity signals on a T2-weighted image. The patients received high-dose methylprednisolone. Their serum was positive for anti-AQP4 antibody (cell-based assay) during the clinical course. They were diagnosed with NMOSD and treated with immunoadsorption, plasmapheresis, and followed up with daily prednisolone. Very-late-onset NMOSD in patients over the age of 80 has only rarely been reported. The present cases suggest that NMOSD should be considered for elderly patients presenting with transverse myelitis. Early diagnosis and treatment are important.
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spelling pubmed-69841492020-01-31 Two Cases of Very-Late-Onset Neuromyelitis Optica Spectrum Disorder (NMOSD) in Patients over the Age of 80 Fujiwara, Shunya Manabe, Yasuhiro Morihara, Ryuta Yunoki, Taijun Kono, Syoichiro Narai, Hisashi Abe, Koji Case Rep Neurol Single Case – General Neurology We report two cases of very-late-onset neuromyelitis optica spectrum disorder (NMOSD) in patients over the age of 80 with transverse myelopathy as the initial manifestation. In both cases, the patients presented with paraplegia and sensory, bladder, and rectal disturbances. Thoracic magnetic resonance imaging showed longitudinal high-intensity signals on a T2-weighted image. The patients received high-dose methylprednisolone. Their serum was positive for anti-AQP4 antibody (cell-based assay) during the clinical course. They were diagnosed with NMOSD and treated with immunoadsorption, plasmapheresis, and followed up with daily prednisolone. Very-late-onset NMOSD in patients over the age of 80 has only rarely been reported. The present cases suggest that NMOSD should be considered for elderly patients presenting with transverse myelitis. Early diagnosis and treatment are important. S. Karger AG 2020-01-09 /pmc/articles/PMC6984149/ /pubmed/32009931 http://dx.doi.org/10.1159/000505231 Text en Copyright © 2020 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc/4.0/ This article is licensed under the Creative Commons Attribution-NonCommercial-4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission.
spellingShingle Single Case – General Neurology
Fujiwara, Shunya
Manabe, Yasuhiro
Morihara, Ryuta
Yunoki, Taijun
Kono, Syoichiro
Narai, Hisashi
Abe, Koji
Two Cases of Very-Late-Onset Neuromyelitis Optica Spectrum Disorder (NMOSD) in Patients over the Age of 80
title Two Cases of Very-Late-Onset Neuromyelitis Optica Spectrum Disorder (NMOSD) in Patients over the Age of 80
title_full Two Cases of Very-Late-Onset Neuromyelitis Optica Spectrum Disorder (NMOSD) in Patients over the Age of 80
title_fullStr Two Cases of Very-Late-Onset Neuromyelitis Optica Spectrum Disorder (NMOSD) in Patients over the Age of 80
title_full_unstemmed Two Cases of Very-Late-Onset Neuromyelitis Optica Spectrum Disorder (NMOSD) in Patients over the Age of 80
title_short Two Cases of Very-Late-Onset Neuromyelitis Optica Spectrum Disorder (NMOSD) in Patients over the Age of 80
title_sort two cases of very-late-onset neuromyelitis optica spectrum disorder (nmosd) in patients over the age of 80
topic Single Case – General Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6984149/
https://www.ncbi.nlm.nih.gov/pubmed/32009931
http://dx.doi.org/10.1159/000505231
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