Age-dependent accumulation of oligomeric SNCA/α-synuclein from impaired degradation in mutant LRRK2 knockin mouse model of Parkinson disease: role for therapeutic activation of chaperone-mediated autophagy (CMA)

Parkinson disease (PD) is an age-related neurodegenerative disorder associated with misfolded SNCA/α-synuclein accumulation in brain. Impaired catabolism of SNCA potentiates formation of its toxic oligomers. LRRK2 (leucine-rich repeat kinase-2) mutations predispose to familial and sporadic PD. Mutan...

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Detalles Bibliográficos
Autores principales: Ho, Philip Wing-Lok, Leung, Chi-Ting, Liu, Huifang, Pang, Shirley Yin-Yu, Lam, Colin Siu-Chi, Xian, Jiawen, Li, Lingfei, Kung, Michelle Hiu-Wai, Ramsden, David Boyer, Ho, Shu-Leong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Translational Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6984454/
https://www.ncbi.nlm.nih.gov/pubmed/30983487
http://dx.doi.org/10.1080/15548627.2019.1603545

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