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Treatment-related changes towards normalization of the abnormal external signal processing in panic disorder

Despite the scientific consensus on the efficacy of psychotherapy for the treatment of psychological disorders, the evidence of treatment-related changes towards normalization of abnormal brain functions in patients is mixed. In the present experiment, we investigated whether treatment can affect ea...

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Detalles Bibliográficos
Autores principales: Valt, Christian, Huber, Dorothea, Stürmer, Birgit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6984717/
https://www.ncbi.nlm.nih.gov/pubmed/31986163
http://dx.doi.org/10.1371/journal.pone.0227673
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author Valt, Christian
Huber, Dorothea
Stürmer, Birgit
author_facet Valt, Christian
Huber, Dorothea
Stürmer, Birgit
author_sort Valt, Christian
collection PubMed
description Despite the scientific consensus on the efficacy of psychotherapy for the treatment of psychological disorders, the evidence of treatment-related changes towards normalization of abnormal brain functions in patients is mixed. In the present experiment, we investigated whether treatment can affect early information processing, by testing abnormal event-related potentials (ERPs) evoked by internal and external signals in panic disorder. Sixteen patients with panic disorder and comorbid personality disorder and sixteen control participants performed a response-choice task and a passive viewing task in two testing sessions, separated by around 14 months. During this period, patients received psychological treatment. In agreement with previous studies of performance monitoring, the abnormal amplitude of the Ne/ERN–an index of error processing based on internal signals—did not change between the first and second testing session. However, treatment-related changes were evident for the abnormal vertex positive potential (VPP) evoked by external signals in the response-choice task and the passive viewing task. In patients, the VPP was smaller in the second session compared to the first session, whereas no significant changes occurred in controls. This result supplies evidence of treatment-related changes towards normalization in the early information processing of external visual stimuli in panic disorder.
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spelling pubmed-69847172020-02-07 Treatment-related changes towards normalization of the abnormal external signal processing in panic disorder Valt, Christian Huber, Dorothea Stürmer, Birgit PLoS One Research Article Despite the scientific consensus on the efficacy of psychotherapy for the treatment of psychological disorders, the evidence of treatment-related changes towards normalization of abnormal brain functions in patients is mixed. In the present experiment, we investigated whether treatment can affect early information processing, by testing abnormal event-related potentials (ERPs) evoked by internal and external signals in panic disorder. Sixteen patients with panic disorder and comorbid personality disorder and sixteen control participants performed a response-choice task and a passive viewing task in two testing sessions, separated by around 14 months. During this period, patients received psychological treatment. In agreement with previous studies of performance monitoring, the abnormal amplitude of the Ne/ERN–an index of error processing based on internal signals—did not change between the first and second testing session. However, treatment-related changes were evident for the abnormal vertex positive potential (VPP) evoked by external signals in the response-choice task and the passive viewing task. In patients, the VPP was smaller in the second session compared to the first session, whereas no significant changes occurred in controls. This result supplies evidence of treatment-related changes towards normalization in the early information processing of external visual stimuli in panic disorder. Public Library of Science 2020-01-27 /pmc/articles/PMC6984717/ /pubmed/31986163 http://dx.doi.org/10.1371/journal.pone.0227673 Text en © 2020 Valt et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Valt, Christian
Huber, Dorothea
Stürmer, Birgit
Treatment-related changes towards normalization of the abnormal external signal processing in panic disorder
title Treatment-related changes towards normalization of the abnormal external signal processing in panic disorder
title_full Treatment-related changes towards normalization of the abnormal external signal processing in panic disorder
title_fullStr Treatment-related changes towards normalization of the abnormal external signal processing in panic disorder
title_full_unstemmed Treatment-related changes towards normalization of the abnormal external signal processing in panic disorder
title_short Treatment-related changes towards normalization of the abnormal external signal processing in panic disorder
title_sort treatment-related changes towards normalization of the abnormal external signal processing in panic disorder
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6984717/
https://www.ncbi.nlm.nih.gov/pubmed/31986163
http://dx.doi.org/10.1371/journal.pone.0227673
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