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Predicting Preeclampsia with Noninvasive Measures of Endothelial Dysfunction: A Pilot Study

Objective  This study evaluates the assessment of endothelial function and its prediction for preeclampsia among women with high-risk factors. Study Design  A prospective cohort study of 107 pregnant women at 20 weeks or greater gestation with risk factors for developing preeclampsia. Endothelial dy...

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Autores principales: Emeasoba, Emmanuel U., McLaren, Rodney A., Landau, Rebecca, Weedon, Jeremy, Haberman, Shoshana, Minkoff, Howard, Shani, Jacob, Montemarano, Nadine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Thieme Medical Publishers 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6984953/
https://www.ncbi.nlm.nih.gov/pubmed/31993247
http://dx.doi.org/10.1055/s-0039-3401806
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author Emeasoba, Emmanuel U.
McLaren, Rodney A.
Landau, Rebecca
Weedon, Jeremy
Haberman, Shoshana
Minkoff, Howard
Shani, Jacob
Montemarano, Nadine
author_facet Emeasoba, Emmanuel U.
McLaren, Rodney A.
Landau, Rebecca
Weedon, Jeremy
Haberman, Shoshana
Minkoff, Howard
Shani, Jacob
Montemarano, Nadine
author_sort Emeasoba, Emmanuel U.
collection PubMed
description Objective  This study evaluates the assessment of endothelial function and its prediction for preeclampsia among women with high-risk factors. Study Design  A prospective cohort study of 107 pregnant women at 20 weeks or greater gestation with risk factors for developing preeclampsia. Endothelial dysfunction was assessed using peripheral arterial tonometry by generating a reactive hyperemia index (RHI) score. An index score of <1.67 was defined as endothelial dysfunction. The primary outcome was preeclampsia. Logistic regression was used to predict preeclampsia from RHI scores, body mass index, gestational age at RHI evaluation, history of preeclampsia, history of pregestational diabetes mellitus, chronic hypertension, and fetal number. A receiver operating characteristic plot was constructed to predict preeclampsia from the RHI score. Results  Among 107 women, 99 had interpretable RHI scores. Among those with an abnormal RHI ( n  = 61), 17 (28%) developed preeclampsia. Among women with a normal score ( n  = 38), six (16%) developed preeclampsia ( p  = 0.166). After logistic regression, there was no significant association. A receiver operating characteristic plot also revealed no association between RHI score and preeclampsia. Conclusion  An abnormal RHI score using peripheral arterial tonometry indicating endothelial dysfunction was not predictive of developing preeclampsia in this cohort. Future studies are needed to further evaluate this relationship.
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spelling pubmed-69849532020-01-28 Predicting Preeclampsia with Noninvasive Measures of Endothelial Dysfunction: A Pilot Study Emeasoba, Emmanuel U. McLaren, Rodney A. Landau, Rebecca Weedon, Jeremy Haberman, Shoshana Minkoff, Howard Shani, Jacob Montemarano, Nadine AJP Rep Objective  This study evaluates the assessment of endothelial function and its prediction for preeclampsia among women with high-risk factors. Study Design  A prospective cohort study of 107 pregnant women at 20 weeks or greater gestation with risk factors for developing preeclampsia. Endothelial dysfunction was assessed using peripheral arterial tonometry by generating a reactive hyperemia index (RHI) score. An index score of <1.67 was defined as endothelial dysfunction. The primary outcome was preeclampsia. Logistic regression was used to predict preeclampsia from RHI scores, body mass index, gestational age at RHI evaluation, history of preeclampsia, history of pregestational diabetes mellitus, chronic hypertension, and fetal number. A receiver operating characteristic plot was constructed to predict preeclampsia from the RHI score. Results  Among 107 women, 99 had interpretable RHI scores. Among those with an abnormal RHI ( n  = 61), 17 (28%) developed preeclampsia. Among women with a normal score ( n  = 38), six (16%) developed preeclampsia ( p  = 0.166). After logistic regression, there was no significant association. A receiver operating characteristic plot also revealed no association between RHI score and preeclampsia. Conclusion  An abnormal RHI score using peripheral arterial tonometry indicating endothelial dysfunction was not predictive of developing preeclampsia in this cohort. Future studies are needed to further evaluate this relationship. Thieme Medical Publishers 2020-01 2020-01-27 /pmc/articles/PMC6984953/ /pubmed/31993247 http://dx.doi.org/10.1055/s-0039-3401806 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License, which permits unrestricted reproduction and distribution, for non-commercial purposes only; and use and reproduction, but not distribution, of adapted material for non-commercial purposes only, provided the original work is properly cited.
spellingShingle Emeasoba, Emmanuel U.
McLaren, Rodney A.
Landau, Rebecca
Weedon, Jeremy
Haberman, Shoshana
Minkoff, Howard
Shani, Jacob
Montemarano, Nadine
Predicting Preeclampsia with Noninvasive Measures of Endothelial Dysfunction: A Pilot Study
title Predicting Preeclampsia with Noninvasive Measures of Endothelial Dysfunction: A Pilot Study
title_full Predicting Preeclampsia with Noninvasive Measures of Endothelial Dysfunction: A Pilot Study
title_fullStr Predicting Preeclampsia with Noninvasive Measures of Endothelial Dysfunction: A Pilot Study
title_full_unstemmed Predicting Preeclampsia with Noninvasive Measures of Endothelial Dysfunction: A Pilot Study
title_short Predicting Preeclampsia with Noninvasive Measures of Endothelial Dysfunction: A Pilot Study
title_sort predicting preeclampsia with noninvasive measures of endothelial dysfunction: a pilot study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6984953/
https://www.ncbi.nlm.nih.gov/pubmed/31993247
http://dx.doi.org/10.1055/s-0039-3401806
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