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Depending on the stress, histone deacetylase inhibitors act as heat shock protein co-inducers in motor neurons and potentiate arimoclomol, exerting neuroprotection through multiple mechanisms in ALS models
Upregulation of heat shock proteins (HSPs) is an approach to treatment of neurodegenerative disorders with impaired proteostasis. Many neurons, including motor neurons affected in amyotrophic lateral sclerosis (ALS), are relatively resistant to stress-induced upregulation of HSPs. This study demonst...
Autores principales: | Kuta, Rachel, Larochelle, Nancy, Fernandez, Mario, Pal, Arun, Minotti, Sandra, Tibshirani, Michael, St. Louis, Kyle, Gentil, Benoit J., Nalbantoglu, Josephine N., Hermann, Andreas, Durham, Heather D. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Netherlands
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6985055/ https://www.ncbi.nlm.nih.gov/pubmed/31900865 http://dx.doi.org/10.1007/s12192-019-01064-1 |
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