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Engineering viable foot-and-mouth disease viruses with increased acid stability facilitate the development of improved vaccines

Foot-and-mouth disease virus (FMDV), the most acid-unstable virus among picornaviruses, tends to disassemble into pentamers at pH values slightly below neutrality. However, the structural integrity of intact virion is one of the most important factors that influence the induction of a protective ant...

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Detalles Bibliográficos
Autores principales:	Yuan, Hong, Li, Pinghua, Bao, Huifang, Sun, Pu, Bai, Xingwen, Bai, Qifeng, Li, Na, Ma, Xueqing, Cao, Yimei, Fu, Yuanfang, Li, Kun, Zhang, Jing, Li, Dong, Chen, Yingli, Zhang, Jie, Lu, Zengjun, Liu, Zaixin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2020
Materias:	Applied Genetics and Molecular Biotechnology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6985056/ https://www.ncbi.nlm.nih.gov/pubmed/31900553 http://dx.doi.org/10.1007/s00253-019-10280-9

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