B4GALNT1 induces angiogenesis, anchorage independence growth and motility, and promotes tumorigenesis in melanoma by induction of ganglioside GM2/GD2

β-1,4-N-Acetyl-Galactosaminyltransferase 1 (B4GALNT1) encodes the key enzyme B4GALNT1 to generate gangliosides GM2/GD2. GM2/GD2 gangliosides are surface glycolipids mainly found on brain neurons as well as peripheral nerves and skin melanocytes and are reported to exacerbate the malignant potential...

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Detalles Bibliográficos
Autores principales: Yoshida, Hideki, Koodie, Lisa, Jacobsen, Kari, Hanzawa, Ken, Miyamoto, Yasuhide, Yamamoto, Masato
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6985110/
https://www.ncbi.nlm.nih.gov/pubmed/31988291
http://dx.doi.org/10.1038/s41598-019-57130-2

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