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Photodynamic Therapy for the Treatment of Glioblastoma

Glioblastoma is the most common form of adult brain cancer and remains one of the deadliest of human cancers. The current standard-of-care involves maximal tumor resection followed by treatment with concurrent radiation therapy and the chemotherapy temozolomide. Recurrence after this therapy is near...

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Autores principales: Cramer, Samuel W., Chen, Clark C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6985206/
https://www.ncbi.nlm.nih.gov/pubmed/32039232
http://dx.doi.org/10.3389/fsurg.2019.00081
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author Cramer, Samuel W.
Chen, Clark C.
author_facet Cramer, Samuel W.
Chen, Clark C.
author_sort Cramer, Samuel W.
collection PubMed
description Glioblastoma is the most common form of adult brain cancer and remains one of the deadliest of human cancers. The current standard-of-care involves maximal tumor resection followed by treatment with concurrent radiation therapy and the chemotherapy temozolomide. Recurrence after this therapy is nearly universal within 2 years of diagnosis. Notably, >80% of recurrence is found in the region adjacent to the resection cavity. The need for improved local control in this region, thus remains unmet. The FDA approval of 5-aminolevulinic acid (5-ALA) for fluorescence guided glioblastoma resection renewed interests in leveraging this agent as a means to administer photodynamic therapy (PDT). Here we review the general principles of PDT as well as the available literature on PDT as a glioblastoma therapeutic platform.
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spelling pubmed-69852062020-02-07 Photodynamic Therapy for the Treatment of Glioblastoma Cramer, Samuel W. Chen, Clark C. Front Surg Surgery Glioblastoma is the most common form of adult brain cancer and remains one of the deadliest of human cancers. The current standard-of-care involves maximal tumor resection followed by treatment with concurrent radiation therapy and the chemotherapy temozolomide. Recurrence after this therapy is nearly universal within 2 years of diagnosis. Notably, >80% of recurrence is found in the region adjacent to the resection cavity. The need for improved local control in this region, thus remains unmet. The FDA approval of 5-aminolevulinic acid (5-ALA) for fluorescence guided glioblastoma resection renewed interests in leveraging this agent as a means to administer photodynamic therapy (PDT). Here we review the general principles of PDT as well as the available literature on PDT as a glioblastoma therapeutic platform. Frontiers Media S.A. 2020-01-21 /pmc/articles/PMC6985206/ /pubmed/32039232 http://dx.doi.org/10.3389/fsurg.2019.00081 Text en Copyright © 2020 Cramer and Chen. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Surgery
Cramer, Samuel W.
Chen, Clark C.
Photodynamic Therapy for the Treatment of Glioblastoma
title Photodynamic Therapy for the Treatment of Glioblastoma
title_full Photodynamic Therapy for the Treatment of Glioblastoma
title_fullStr Photodynamic Therapy for the Treatment of Glioblastoma
title_full_unstemmed Photodynamic Therapy for the Treatment of Glioblastoma
title_short Photodynamic Therapy for the Treatment of Glioblastoma
title_sort photodynamic therapy for the treatment of glioblastoma
topic Surgery
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6985206/
https://www.ncbi.nlm.nih.gov/pubmed/32039232
http://dx.doi.org/10.3389/fsurg.2019.00081
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