Cargando…

Genetically stable poliovirus vectors activate dendritic cells and prime antitumor CD8 T cell immunity

Viruses naturally engage innate immunity, induce antigen presentation, and mediate CD8 T cell priming against foreign antigens. Polioviruses can provide a context optimal for generating antigen-specific CD8 T cells, as they have natural tropism for dendritic cells, preeminent inducers of CD8 T cell...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mosaheb, Mubeen M., Dobrikova, Elena Y., Brown, Michael C., Yang, Yuanfan, Cable, Jana, Okada, Hideho, Nair, Smita K., Bigner, Darell D., Ashley, David M., Gromeier, Matthias
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6985231/ https://www.ncbi.nlm.nih.gov/pubmed/31988324 http://dx.doi.org/10.1038/s41467-019-13939-z

Ejemplares similares

THER-05. GENETICALLY STABLE POLIOVIRUS VECTOR CARRYING H3.3K27M ANTIGEN FOR TREATMENT OF DIFFUSE MIDLINE GLIOMA BY INTRAMUSCULAR INJECTION
por: Mosaheb, Mubeen, et al.
Publicado: (2020)

Oncolytic poliovirus directs tumor antigen presentation and T cell activation in vitro
por: Brown, Michael C, et al.
Publicado: (2015)

Viral infection of cells within the tumor microenvironment mediates antitumor immunotherapy via selective TBK1-IRF3 signaling
por: Brown, Michael C., et al.
Publicado: (2021)

Intratumor childhood vaccine-specific CD4(+) T-cell recall coordinates antitumor CD8(+) T cells and eosinophils
por: Brown, Michael C, et al.
Publicado: (2023)

Recombinant oncolytic poliovirus, PVSRIPO, has potent cytotoxic and innate inflammatory effects, mediating therapy in human breast and prostate cancer xenograft models
por: Holl, Eda K., et al.
Publicado: (2016)

Bone Marrow–generated Dendritic Cells Pulsed with Tumor Extracts or Tumor RNA Induce Antitumor Immunity against Central Nervous System Tumors
por: Ashley, David M., et al.
Publicado: (1997)

Synergistic antitumor effects of 9.2.27-PE38KDEL and ABT-737 in primary and metastatic brain tumors
por: Yu, Xin, et al.
Publicado: (2019)

Mouse neuropathogenic poliovirus strains cause damage in the central nervous system distinct from poliomyelitis
por: Gromeier, Matthias, et al.
Publicado: (1995)

Phase I trial of intratumoral PVSRIPO in patients with unresectable, treatment-refractory melanoma
por: Beasley, Georgia M, et al.
Publicado: (2021)

Improved efficacy against malignant brain tumors with EGFRwt/EGFRvIII targeting immunotoxin and checkpoint inhibitor combinations
por: Chandramohan, Vidyalakshmi, et al.
Publicado: (2019)

Multimodality analysis confers a prognostic benefit of a T-cell infiltrated tumor microenvironment and peripheral immune status in patients with melanoma
por: Beasley, Georgia M, et al.
Publicado: (2022)

Type I Interferon-Independent Dendritic Cell Priming and Antitumor T Cell Activation Induced by a Mycoplasma fermentans Lipopeptide
por: Takeda, Yohei, et al.
Publicado: (2018)

A novel recombinant immunotoxin-based therapy targeting wild-type and mutant EGFR improves survival in murine models of glioblastoma
por: Chandramohan, Vidyalakshmi, et al.
Publicado: (2013)

CReP mediates selective translation initiation at the endoplasmic reticulum
por: Kastan, Jonathan P., et al.
Publicado: (2020)

Tissue Type-Specific Expression of the dsRNA-Binding Protein 76 and Genome-Wide Elucidation of Its Target mRNAs
por: Neplioueva, Valentina, et al.
Publicado: (2010)

A novel bispecific antibody recruits T cells to eradicate tumors in the “immunologically privileged” central nervous system
por: Choi, Bryan D., et al.
Publicado: (2013)

An innovative plasmacytoid dendritic cell line-based cancer vaccine primes and expands antitumor T-cells in melanoma patients in a first-in-human trial
por: Charles, Julie, et al.
Publicado: (2020)

Role of dendritic cells in the regulation of antitumor immunity
por: Wathelet, Nathalie, et al.
Publicado: (2013)

TAP dysfunction in dendritic cells enables non-canonical cross-presentation for T cell priming
por: Barbet, Gaëtan, et al.
Publicado: (2021)

SYST-12 D2C7 CAR: A NOVEL CAR T CELL THAT SIMULTANEOUSLY TARGETS WILDTYPE EGFR AND ITS MUTANT ISOFORM EGFRVIII FOR TREATMENT OF GLIOMA AND BRAIN METASTASES
por: Wilkinson, Daniel, et al.
Publicado: (2022)

Mobilizing Dendritic Cells for Tolerance, Priming, and Chronic Inflammation
por: Sallusto, Federica, et al.
Publicado: (1999)

Hybrid LNP Prime Dendritic Cells for Nucleotide Delivery
por: Das, Riddha, et al.
Publicado: (2023)

Imaging Poliovirus Entry in Live Cells
por: Brandenburg, Boerries, et al.
Publicado: (2007)

Aberrant Otx2 Expression Enhances Migration and Induces Ectopic Proliferation of Hindbrain Neuronal Progenitor Cells
por: Wortham, Matthew, et al.
Publicado: (2012)

EGFR/EGFRvIII-targeted immunotoxin therapy for the treatment of glioblastomas via convection-enhanced delivery
por: Bao, Xuhui, et al.
Publicado: (2016)

Regulatory T cells are redirected to kill glioblastoma by an EGFRvIII-targeted bispecific antibody
por: Choi, Bryan D, et al.
Publicado: (2013)

L-Myc expression by dendritic cells is required for optimal T-cell priming
por: Wumesh, KC, et al.
Publicado: (2014)

Myocardial Infarction Primes Autoreactive T Cells through Activation of Dendritic Cells
por: Van der Borght, Katrien, et al.
Publicado: (2017)

Decoupling of DNA damage response signaling from DNA damages underlies temozolomide resistance in glioblastoma cells()
por: Cui, Bo, et al.
Publicado: (2010)

Elevated expression of podoplanin and its clinicopathological, prognostic, and therapeutic values in squamous non-small cell lung cancer
por: Xie, Liyi, et al.
Publicado: (2018)

HIV/SIV Infection Primes Monocytes and Dendritic Cells for Apoptosis
por: Laforge, Mireille, et al.
Publicado: (2011)

Ready for Prime Time? Dendritic Cells in High-Grade Gliomas
por: Conarroe, Claire A., et al.
Publicado: (2023)

Toxin-Based Targeted Therapy for Malignant Brain Tumors
por: Chandramohan, Vidyalakshmi, et al.
Publicado: (2012)

THE CYTOCHEMICAL EXAMINATION OF POLIOVIRUS-INDUCED CELL DAMAGE
por: Heding, Linda D., et al.
Publicado: (1973)

Antitumor efficacy of D2C7-(scdsFv)-PE38KDEL, a novel immunotoxin targeting EGFRwt and EGFRvIII, by convection-enhanced delivery in orthotopic brain tumor mouse models
por: Bao, Xuhui, et al.
Publicado: (2013)

Direct detection of polioviruses using a recombinant poliovirus receptor
por: Gerloff, Nancy, et al.
Publicado: (2021)

Metabolic glycan labeling immobilizes dendritic cell membrane and enhances antitumor efficacy of dendritic cell vaccine
por: Han, Joonsu, et al.
Publicado: (2023)

OTME-16. Polio virotherapy of murine brain tumors causes microglia/macrophage proliferation and inflammation that is potentiated by immune checkpoint blockade
por: Yang, Yuanfan, et al.
Publicado: (2021)

Dendritic Cells The Tumor Microenvironment and the Challenges for an Effective Antitumor Vaccination
por: Benencia, Fabian, et al.
Publicado: (2012)

Mouse T cell priming is enhanced by maturation-dependent stiffening of the dendritic cell cortex
por: Blumenthal, Daniel, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_7cttk3ffvl3hfjd4jn06hvj06o