Integrative analysis reveals RNA G-quadruplexes in UTRs are selectively constrained and enriched for functional associations

G-quadruplex (G4) sequences are abundant in untranslated regions (UTRs) of human messenger RNAs, but their functional importance remains unclear. By integrating multiple sources of genetic and genomic data, we show that putative G-quadruplex forming sequences (pG4) in 5’ and 3’ UTRs are selectively...

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Detalles Bibliográficos
Autores principales: Lee, David S. M., Ghanem, Louis R., Barash, Yoseph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6985247/
https://www.ncbi.nlm.nih.gov/pubmed/31988292
http://dx.doi.org/10.1038/s41467-020-14404-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6985247/
https://www.ncbi.nlm.nih.gov/pubmed/31988292
http://dx.doi.org/10.1038/s41467-020-14404-y

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