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Altering microtubule dynamics is synergistically toxic with spindle assembly checkpoint inhibition

Chromosomal instability (CIN) and aneuploidy are hallmarks of cancer. As most cancers are aneuploid, targeting aneuploidy or CIN may be an effective way to target a broad spectrum of cancers. Here, we perform two small molecule compound screens to identify drugs that selectively target cells that ar...

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Detalles Bibliográficos
Autores principales:	Schukken, Klaske M, Lin, Yu-Chih, Bakker, Petra L, Schubert, Michael, Preuss, Stephanie F, Simon, Judith E, van den Bos, Hilda, Storchova, Zuzana, Colomé-Tatché, Maria, Bastians, Holger, Spierings, Diana CJ, Foijer, Floris
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Life Science Alliance LLC 2020
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6985455/ https://www.ncbi.nlm.nih.gov/pubmed/31980556 http://dx.doi.org/10.26508/lsa.201900499

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