Cargando…
Comprehensive Analysis of Competitive Endogenous RNAs Network, Being Associated With Esophageal Squamous Cell Carcinoma and Its Emerging Role in Head and Neck Squamous Cell Carcinoma
Esophageal squamous cell carcinoma (ESCC) is a common malignancy with poor prognosis and survival rate. To identify meaningful long non-coding RNA (lncRNA), microRNA (miRNA), and messenger RNA (mRNA) modules related to the ESCC prognosis, The Cancer Genome Atlas-ESCC was downloaded and processed, an...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6985543/ https://www.ncbi.nlm.nih.gov/pubmed/32038997 http://dx.doi.org/10.3389/fonc.2019.01474 |
_version_ | 1783491824866820096 |
---|---|
author | Yu, Donghu Ruan, Xiaolan Huang, Jingyu Hu, Weidong Chen, Chen Xu, Yu Hou, Jinxuan Li, Sheng |
author_facet | Yu, Donghu Ruan, Xiaolan Huang, Jingyu Hu, Weidong Chen, Chen Xu, Yu Hou, Jinxuan Li, Sheng |
author_sort | Yu, Donghu |
collection | PubMed |
description | Esophageal squamous cell carcinoma (ESCC) is a common malignancy with poor prognosis and survival rate. To identify meaningful long non-coding RNA (lncRNA), microRNA (miRNA), and messenger RNA (mRNA) modules related to the ESCC prognosis, The Cancer Genome Atlas-ESCC was downloaded and processed, and then, a weighted gene co-expression network analysis was applied to construct lncRNA co-expression networks, miRNA co-expression networks, and mRNA co-expression networks. Twenty-one hub lncRNAs, seven hub miRNAs, and eight hub mRNAs were clarified. Additionally, a competitive endogenous RNAs network was constructed, and the emerging role of the network involved in head and neck squamous cell carcinoma (HNSCC) was also analyzed using several webtools. The expression levels of eight hub genes (TBC1D2, ATP6V0E1, SPI1, RNASE6, C1QB, C1QC, CSF1R, and C1QA) were different between normal esophageal tissues and HNSCC tissues. The expression levels of TBC1D2 and ATP6V0E1 were related to the survival time of HNSCC. The competitive endogenous RNAs network might provide common mechanisms involving in ESCC and HNSCC. More importantly, useful clues were provided for clinical treatments of both diseases based on novel molecular advances. |
format | Online Article Text |
id | pubmed-6985543 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-69855432020-02-07 Comprehensive Analysis of Competitive Endogenous RNAs Network, Being Associated With Esophageal Squamous Cell Carcinoma and Its Emerging Role in Head and Neck Squamous Cell Carcinoma Yu, Donghu Ruan, Xiaolan Huang, Jingyu Hu, Weidong Chen, Chen Xu, Yu Hou, Jinxuan Li, Sheng Front Oncol Oncology Esophageal squamous cell carcinoma (ESCC) is a common malignancy with poor prognosis and survival rate. To identify meaningful long non-coding RNA (lncRNA), microRNA (miRNA), and messenger RNA (mRNA) modules related to the ESCC prognosis, The Cancer Genome Atlas-ESCC was downloaded and processed, and then, a weighted gene co-expression network analysis was applied to construct lncRNA co-expression networks, miRNA co-expression networks, and mRNA co-expression networks. Twenty-one hub lncRNAs, seven hub miRNAs, and eight hub mRNAs were clarified. Additionally, a competitive endogenous RNAs network was constructed, and the emerging role of the network involved in head and neck squamous cell carcinoma (HNSCC) was also analyzed using several webtools. The expression levels of eight hub genes (TBC1D2, ATP6V0E1, SPI1, RNASE6, C1QB, C1QC, CSF1R, and C1QA) were different between normal esophageal tissues and HNSCC tissues. The expression levels of TBC1D2 and ATP6V0E1 were related to the survival time of HNSCC. The competitive endogenous RNAs network might provide common mechanisms involving in ESCC and HNSCC. More importantly, useful clues were provided for clinical treatments of both diseases based on novel molecular advances. Frontiers Media S.A. 2020-01-21 /pmc/articles/PMC6985543/ /pubmed/32038997 http://dx.doi.org/10.3389/fonc.2019.01474 Text en Copyright © 2020 Yu, Ruan, Huang, Hu, Chen, Xu, Hou and Li. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Yu, Donghu Ruan, Xiaolan Huang, Jingyu Hu, Weidong Chen, Chen Xu, Yu Hou, Jinxuan Li, Sheng Comprehensive Analysis of Competitive Endogenous RNAs Network, Being Associated With Esophageal Squamous Cell Carcinoma and Its Emerging Role in Head and Neck Squamous Cell Carcinoma |
title | Comprehensive Analysis of Competitive Endogenous RNAs Network, Being Associated With Esophageal Squamous Cell Carcinoma and Its Emerging Role in Head and Neck Squamous Cell Carcinoma |
title_full | Comprehensive Analysis of Competitive Endogenous RNAs Network, Being Associated With Esophageal Squamous Cell Carcinoma and Its Emerging Role in Head and Neck Squamous Cell Carcinoma |
title_fullStr | Comprehensive Analysis of Competitive Endogenous RNAs Network, Being Associated With Esophageal Squamous Cell Carcinoma and Its Emerging Role in Head and Neck Squamous Cell Carcinoma |
title_full_unstemmed | Comprehensive Analysis of Competitive Endogenous RNAs Network, Being Associated With Esophageal Squamous Cell Carcinoma and Its Emerging Role in Head and Neck Squamous Cell Carcinoma |
title_short | Comprehensive Analysis of Competitive Endogenous RNAs Network, Being Associated With Esophageal Squamous Cell Carcinoma and Its Emerging Role in Head and Neck Squamous Cell Carcinoma |
title_sort | comprehensive analysis of competitive endogenous rnas network, being associated with esophageal squamous cell carcinoma and its emerging role in head and neck squamous cell carcinoma |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6985543/ https://www.ncbi.nlm.nih.gov/pubmed/32038997 http://dx.doi.org/10.3389/fonc.2019.01474 |
work_keys_str_mv | AT yudonghu comprehensiveanalysisofcompetitiveendogenousrnasnetworkbeingassociatedwithesophagealsquamouscellcarcinomaanditsemergingroleinheadandnecksquamouscellcarcinoma AT ruanxiaolan comprehensiveanalysisofcompetitiveendogenousrnasnetworkbeingassociatedwithesophagealsquamouscellcarcinomaanditsemergingroleinheadandnecksquamouscellcarcinoma AT huangjingyu comprehensiveanalysisofcompetitiveendogenousrnasnetworkbeingassociatedwithesophagealsquamouscellcarcinomaanditsemergingroleinheadandnecksquamouscellcarcinoma AT huweidong comprehensiveanalysisofcompetitiveendogenousrnasnetworkbeingassociatedwithesophagealsquamouscellcarcinomaanditsemergingroleinheadandnecksquamouscellcarcinoma AT chenchen comprehensiveanalysisofcompetitiveendogenousrnasnetworkbeingassociatedwithesophagealsquamouscellcarcinomaanditsemergingroleinheadandnecksquamouscellcarcinoma AT xuyu comprehensiveanalysisofcompetitiveendogenousrnasnetworkbeingassociatedwithesophagealsquamouscellcarcinomaanditsemergingroleinheadandnecksquamouscellcarcinoma AT houjinxuan comprehensiveanalysisofcompetitiveendogenousrnasnetworkbeingassociatedwithesophagealsquamouscellcarcinomaanditsemergingroleinheadandnecksquamouscellcarcinoma AT lisheng comprehensiveanalysisofcompetitiveendogenousrnasnetworkbeingassociatedwithesophagealsquamouscellcarcinomaanditsemergingroleinheadandnecksquamouscellcarcinoma |