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Age-Dependent Decline in Cardiac Function in Guanidinoacetate-N-Methyltransferase Knockout Mice

AIM: Guanidinoacetate N-methyltransferase (GAMT) is the second essential enzyme in creatine (Cr) biosynthesis. Short-term Cr deficiency is metabolically well tolerated as GAMT(–/–) mice exhibit normal exercise capacity and response to ischemic heart failure. However, we hypothesized long-term conseq...

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Detalles Bibliográficos
Autores principales:	Aksentijević, Dunja, Zervou, Sevasti, Eykyn, Thomas R., McAndrew, Debra J., Wallis, Julie, Schneider, Jurgen E., Neubauer, Stefan, Lygate, Craig A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Physiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6985570/ https://www.ncbi.nlm.nih.gov/pubmed/32038270 http://dx.doi.org/10.3389/fphys.2019.01535

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