Suppression of AMP‐activated protein kinase reverses osteoprotegerin‐induced inhibition of osteoclast differentiation by reducing autophagy

OBJECTIVES: Osteoclasts (OC) are unique terminally differentiated cells whose primary function is bone resorption. We previously showed that osteoprotegerin (OPG) inhibits OC differentiation in vitro by enhancing autophagy via the adenosine monophosphate‐activated protein kinase (AMPK)/mTOR/p70S6K s...

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Detalles Bibliográficos
Autores principales: Tong, Xishuai, Zhang, Chuang, Wang, Dong, Song, Ruilong, Ma, Yonggang, Cao, Ying, Zhao, Hongyan, Bian, Jianchun, Gu, Jianhong, Liu, Zongping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6985670/
https://www.ncbi.nlm.nih.gov/pubmed/31696568
http://dx.doi.org/10.1111/cpr.12714

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6985670/
https://www.ncbi.nlm.nih.gov/pubmed/31696568
http://dx.doi.org/10.1111/cpr.12714

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