Cargando…

Pre‐clinical evidences for the efficacy of tryptanthrin as a potent suppressor of skin cancer

OBJECTIVE: Clinical trials have demonstrated the efficacy of indigo naturalis, a traditional Chinese medicine ingredient, against psoriasis, a skin disease characterized by keratinocyte hyperproliferation and inflammation. The present study investigates the efficacy of tryptanthrin, a bioactive comp...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shankar G., Mohan, Alex, Vijai V., Nisthul A., Amrutha, Bava, Smitha V., Sundaram, Sankar, Retnakumari, Archana P., Chittalakkottu, Sadasivan, Anto, Ruby John
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2019
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6985671/ https://www.ncbi.nlm.nih.gov/pubmed/31663659 http://dx.doi.org/10.1111/cpr.12710

Ejemplares similares

Targeting Thymidylate Synthase Enhances the Chemosensitivity of Triple-Negative Breast Cancer Towards 5-FU-Based Combinatorial Therapy
por: Haritha, Nair Hariprasad, et al.
Publicado: (2021)

A potent bioactive fraction against colon cancer from Plectranthus vettiveroides
por: Athikkavil, Faisal M., et al.
Publicado: (2023)

Folic acid conjugation improves the bioavailability and chemosensitizing efficacy of curcumin-encapsulated PLGA-PEG nanoparticles towards paclitaxel chemotherapy
por: Thulasidasan, Arun Kumar T., et al.
Publicado: (2017)

Therapeutic Effects of Tryptanthrin and Tryptanthrin-6-Oxime in Models of Rheumatoid Arthritis
por: Kirpotina, Liliya N., et al.
Publicado: (2020)

Identification of CD4(+) T cell epitopes from Staphylococcus aureus secretome using immunoinformatic prediction and molecular docking
por: Francis, Dileep, et al.
Publicado: (2021)

Synthesis and evaluation of the antiplasmodial activity of tryptanthrin derivatives
por: Onambele, Liliane Abodo, et al.
Publicado: (2015)

Targeting K-Ras and apoptosis-driven cellular transformation in cancer
por: Godwin, Isha, et al.
Publicado: (2021)

Identification of Mutations Conferring Tryptanthrin Resistance to Mycobacterium smegmatis
por: Frolova, Svetlana G., et al.
Publicado: (2020)

Corrigendum: Cucurbitacin B, purified and characterized from the rhizome of Corallocarpus epigaeus exhibits anti-melanoma potential
por: Aiswarya, Sreekumar Usha Devi, et al.
Publicado: (2022)

Cucurbitacin B, Purified and Characterized From the Rhizome of Corallocarpus epigaeus Exhibits Anti-Melanoma Potential
por: Aiswarya, Sreekumar Usha Devi, et al.
Publicado: (2022)

A novel protein fraction from Sesbania grandiflora shows potential anticancer and chemopreventive efficacy, in vitro and in vivo
por: Laladhas, Krishna P, et al.
Publicado: (2010)

Heteronemin, a marine natural product, sensitizes acute myeloid leukemia cells towards cytarabine chemotherapy by regulating farnesylation of Ras
por: Saikia, Minakshi, et al.
Publicado: (2018)

[6]-Gingerol Induces Caspase-Dependent Apoptosis and Prevents PMA-Induced Proliferation in Colon Cancer Cells by Inhibiting MAPK/AP-1 Signaling
por: Radhakrishnan, EK, et al.
Publicado: (2014)

The Natural Alkaloid Tryptanthrin Induces Apoptosis-like Death in Leishmania spp.
por: Garcia, Andreza R., et al.
Publicado: (2022)

Novel Tryptanthrin Derivatives with Selectivity as c–Jun N–Terminal Kinase (JNK) 3 Inhibitors
por: Schepetkin, Igor A., et al.
Publicado: (2023)

Neuroprotective Effects of Tryptanthrin-6-Oxime in a Rat Model of Transient Focal Cerebral Ischemia
por: Plotnikov, Mark B., et al.
Publicado: (2023)

(Nitrato-κ(2) O,O′)bis(tryptanthrin-κN)silver(I)
por: Wu, Jie, et al.
Publicado: (2012)

Design, synthesis and biomedical evaluation of mostotrin, a new water soluble tryptanthrin derivative
por: Popov, Alexander, et al.
Publicado: (2020)

LC-APCI-MS method for detection and analysis of tryptanthrin, indigo, and indirubin in Daqingye and Banlangen
por: Liau, Bing-Chung, et al.
Publicado: (2007)

Tryptanthrin attenuates TLR3-mediated STAT1 activation in THP-1 cells
por: Numao, Noriyuki, et al.
Publicado: (2022)

Discovery and Mechanism of Novel 7-Aliphatic Amine Tryptanthrin Derivatives against Phytopathogenic Bacteria
por: Long, Xuesha, et al.
Publicado: (2023)

Tryptanthrin inhibits tumor angiogenesis via Notch/Dll4 signaling pathway in zebrafish
por: Lin, Meimei, et al.
Publicado: (2023)

Nicotine-induced survival signaling in lung cancer cells is dependent on their p53 status while its down-regulation by curcumin is independent
por: Puliyappadamba, Vineshkumar T, et al.
Publicado: (2010)

Identification of Spiro-Fused Pyrrolo[3,4-a]pyrrolizines and Tryptanthrines as Potential Antitumor Agents: Synthesis and In Vitro Evaluation
por: Latypova, Diana K., et al.
Publicado: (2021)

Tryptanthrin Inhibits Angiogenesis by Targeting the VEGFR2-Mediated ERK1/2 Signalling Pathway
por: Liao, Xuemei, et al.
Publicado: (2013)

Tryptanthrin promotes keratinocyte and fibroblast responses in vitro after infection with Trichophyton benhamiae DSM6916
por: Hesse-Macabata, Jana, et al.
Publicado: (2020)

Sulfonated tryptanthrin anolyte increases performance in pH neutral aqueous redox flow batteries
por: Pinheiro, Daniela, et al.
Publicado: (2021)

Antiviral Action of Tryptanthrin Isolated from Strobilanthes cusia Leaf against Human Coronavirus NL63
por: Tsai, Yu-Chi, et al.
Publicado: (2020)

Discovery of Novel Tryptanthrin Derivatives with Benzenesulfonamide Substituents as Multi-Target-Directed Ligands for the Treatment of Alzheimer’s Disease
por: Wang, Guoxing, et al.
Publicado: (2023)

Childhood caries as influenced by maternal and child characteristics in pre-school children of Kerala-an epidemiological study
por: Retnakumari, N., et al.
Publicado: (2012)

Novel Fe(II) and Co(II) Complexes of Natural Product Tryptanthrin: Synthesis and Binding with G-Quadruplex DNA
por: Zhong, Yi-ning, et al.
Publicado: (2016)

Discovery of Tryptanthrin and Its Derivatives and Its Activities against NSCLC In Vitro via Both Apoptosis and Autophagy Pathways
por: Zou, Yayu, et al.
Publicado: (2023)

Proliferation-Attenuating and Apoptosis-Inducing Effects of Tryptanthrin on Human Chronic Myeloid Leukemia K562 Cell Line in Vitro
por: Miao, Shan, et al.
Publicado: (2011)

Synthetic Tryptanthrin Derivatives Induce Cell Cycle Arrest and Apoptosis via Akt and MAPKs in Human Hepatocellular Carcinoma Cells
por: Gao, Jing-Yan, et al.
Publicado: (2021)

Auranofin is a potent suppressor of osteosarcoma metastasis
por: Topkas, Eleni, et al.
Publicado: (2015)

Design, synthesis and biological evaluation of novel O-substituted tryptanthrin oxime derivatives as c-Jun N-terminal kinase inhibitors
por: Schepetkin, Igor A., et al.
Publicado: (2022)

Tryptanthrin Suppresses the Activation of the LPS-Treated BV2 Microglial Cell Line via Nrf2/HO-1 Antioxidant Signaling
por: Kwon, Young-Won, et al.
Publicado: (2017)

Exploiting 1,2,3-Triazolium Ionic Liquids for Synthesis of Tryptanthrin and Chemoselective Extraction of Copper(II) Ions and Histidine-Containing Peptides
por: Li, Hsin-Yi, et al.
Publicado: (2016)

PIMT is a novel and potent suppressor of endothelial activation
por: Zhang, Chen, et al.
Publicado: (2023)

Cancer Chemoprevention: A Strategic Approach Using Phytochemicals
por: G., Mohan Shankar, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_tcvmdg1ptu0eolvds68p7lpamf