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Automated phase unwrapping in Doppler optical coherence tomography

Phase wrapping is a crucial issue in Doppler optical coherence tomography (OCT) and restricts its automatic implementation for clinical applications that quantify total retinal blood flow. We propose an automated phase-unwrapping technique that takes advantage of the parabolic profile of blood flow...

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Autores principales: Pi, Shaohua, Camino, Acner, Wei, Xiang, Hormel, Tristan T., Cepurna, William, Morrison, John C., Jia, Yali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society of Photo-Optical Instrumentation Engineers 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6985683/
https://www.ncbi.nlm.nih.gov/pubmed/30701724
http://dx.doi.org/10.1117/1.JBO.24.1.010502
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author Pi, Shaohua
Camino, Acner
Wei, Xiang
Hormel, Tristan T.
Cepurna, William
Morrison, John C.
Jia, Yali
author_facet Pi, Shaohua
Camino, Acner
Wei, Xiang
Hormel, Tristan T.
Cepurna, William
Morrison, John C.
Jia, Yali
author_sort Pi, Shaohua
collection PubMed
description Phase wrapping is a crucial issue in Doppler optical coherence tomography (OCT) and restricts its automatic implementation for clinical applications that quantify total retinal blood flow. We propose an automated phase-unwrapping technique that takes advantage of the parabolic profile of blood flow velocity in vessels. Instead of inspecting the phase shift manually, the algorithm calculates the gradient magnitude of the phase shift on the cross-sectional image and automatically detects the presence of phase wrapping. The voxels affected by phase wrapping are corrected according to the determined flow direction adjacent to the vessel walls. We validated this technique in the rodent retina using a prototype visible-light OCT and in the human retina with a commercial infrared OCT system. We believe this signal processing method may well accelerate clinical applications of Doppler OCT in ophthalmology.
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spelling pubmed-69856832020-02-03 Automated phase unwrapping in Doppler optical coherence tomography Pi, Shaohua Camino, Acner Wei, Xiang Hormel, Tristan T. Cepurna, William Morrison, John C. Jia, Yali J Biomed Opt JBO Letters Phase wrapping is a crucial issue in Doppler optical coherence tomography (OCT) and restricts its automatic implementation for clinical applications that quantify total retinal blood flow. We propose an automated phase-unwrapping technique that takes advantage of the parabolic profile of blood flow velocity in vessels. Instead of inspecting the phase shift manually, the algorithm calculates the gradient magnitude of the phase shift on the cross-sectional image and automatically detects the presence of phase wrapping. The voxels affected by phase wrapping are corrected according to the determined flow direction adjacent to the vessel walls. We validated this technique in the rodent retina using a prototype visible-light OCT and in the human retina with a commercial infrared OCT system. We believe this signal processing method may well accelerate clinical applications of Doppler OCT in ophthalmology. Society of Photo-Optical Instrumentation Engineers 2019-01-30 2019-01 /pmc/articles/PMC6985683/ /pubmed/30701724 http://dx.doi.org/10.1117/1.JBO.24.1.010502 Text en © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.
spellingShingle JBO Letters
Pi, Shaohua
Camino, Acner
Wei, Xiang
Hormel, Tristan T.
Cepurna, William
Morrison, John C.
Jia, Yali
Automated phase unwrapping in Doppler optical coherence tomography
title Automated phase unwrapping in Doppler optical coherence tomography
title_full Automated phase unwrapping in Doppler optical coherence tomography
title_fullStr Automated phase unwrapping in Doppler optical coherence tomography
title_full_unstemmed Automated phase unwrapping in Doppler optical coherence tomography
title_short Automated phase unwrapping in Doppler optical coherence tomography
title_sort automated phase unwrapping in doppler optical coherence tomography
topic JBO Letters
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6985683/
https://www.ncbi.nlm.nih.gov/pubmed/30701724
http://dx.doi.org/10.1117/1.JBO.24.1.010502
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