Withaferin A triggers G2/M arrest and intrinsic apoptosis in glioblastoma cells via ATF4‐ATF3‐CHOP axis

OBJECTIVE: Withaferin A (WA) is a bioactive compound with a remarkable anti‐cancer effect derived from Withania somnifera, commonly known as ashwagandha. However, the anti‐cancer mechanisms of WA in glioblastoma multiforme (GBM) are still unclear. MATERIALS AND METHODS: Cell viability assays and xen...

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Detalles Bibliográficos
Autores principales: Tang, Qin, Ren, Liwen, Liu, Jinyi, Li, Wan, Zheng, Xiangjin, Wang, Jinhua, Du, Guanhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6985693/
https://www.ncbi.nlm.nih.gov/pubmed/31642559
http://dx.doi.org/10.1111/cpr.12706

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6985693/
https://www.ncbi.nlm.nih.gov/pubmed/31642559
http://dx.doi.org/10.1111/cpr.12706

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