Hedgehog signaling promotes sorafenib resistance in hepatocellular carcinoma patient-derived organoids

BACKGROUND: The mechanism underlying sorafenib resistance in hepatocellular carcinoma (HCC) remains unclear. Accumulating evidence suggests that tumor-initiating cells (TICs) are a pivotal driving force. Both CD44 and Hedgehog signaling play crucial roles in TIC properties in HCC. In this study, we...

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Detalles Bibliográficos
Autores principales: Wang, Siqi, Wang, Yang, Xun, Xiaodong, Zhang, Changkun, Xiang, Xiao, Cheng, Qian, Hu, Shihua, Li, Zhao, Zhu, Jiye
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6986013/
https://www.ncbi.nlm.nih.gov/pubmed/31992334
http://dx.doi.org/10.1186/s13046-020-1523-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6986013/
https://www.ncbi.nlm.nih.gov/pubmed/31992334
http://dx.doi.org/10.1186/s13046-020-1523-2

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