Cargando…
Hedgehog signaling promotes sorafenib resistance in hepatocellular carcinoma patient-derived organoids
BACKGROUND: The mechanism underlying sorafenib resistance in hepatocellular carcinoma (HCC) remains unclear. Accumulating evidence suggests that tumor-initiating cells (TICs) are a pivotal driving force. Both CD44 and Hedgehog signaling play crucial roles in TIC properties in HCC. In this study, we...
Autores principales: | Wang, Siqi, Wang, Yang, Xun, Xiaodong, Zhang, Changkun, Xiang, Xiao, Cheng, Qian, Hu, Shihua, Li, Zhao, Zhu, Jiye |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6986013/ https://www.ncbi.nlm.nih.gov/pubmed/31992334 http://dx.doi.org/10.1186/s13046-020-1523-2 |
Ejemplares similares
-
TIGIT Can Exert Immunosuppressive Effects on CD8(+) T Cells by the CD155/TIGIT Signaling Pathway for Hepatocellular Carcinoma In Vitro
por: Zhang, Changkun, et al.
Publicado: (2020) -
The current status of tumor microenvironment and cancer stem cells in sorafenib resistance of hepatocellular carcinoma
por: Chen, Siqi, et al.
Publicado: (2023) -
Camptothecin improves sorafenib sensitivity by inhibiting Nrf2‑ARE pathway in hepatocellular carcinoma
por: Sun, Liwei, et al.
Publicado: (2023) -
Silencing KIF14 reverses acquired resistance to sorafenib in hepatocellular carcinoma
por: Zhu, Qiankun, et al.
Publicado: (2020) -
MCM2 promotes the stemness and sorafenib resistance of hepatocellular carcinoma cells via hippo signaling
por: Zhou, Xin, et al.
Publicado: (2022)