Choice of library size normalization and statistical methods for differential gene expression analysis in balanced two-group comparisons for RNA-seq studies

BACKGROUND: High-throughput RNA sequencing (RNA-seq) has evolved as an important analytical tool in molecular biology. Although the utility and importance of this technique have grown, uncertainties regarding the proper analysis of RNA-seq data remain. Of primary concern, there is no consensus regar...

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Detalles Bibliográficos
Autores principales: Li, Xiaohong, Cooper, Nigel G. F., O’Toole, Timothy E., Rouchka, Eric C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6986029/
https://www.ncbi.nlm.nih.gov/pubmed/31992223
http://dx.doi.org/10.1186/s12864-020-6502-7

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