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FocAn: automated 3D analysis of DNA repair foci in image stacks acquired by confocal fluorescence microscopy
BACKGROUND: Phosphorylated histone H2AX, also known as γH2AX, forms μm-sized nuclear foci at the sites of DNA double-strand breaks (DSBs) induced by ionizing radiation and other agents. Due to their specificity and sensitivity, γH2AX immunoassays have become the gold standard for studying DSB induct...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6986076/ https://www.ncbi.nlm.nih.gov/pubmed/31992200 http://dx.doi.org/10.1186/s12859-020-3370-8 |