Cargando…

Ubiquitin-specific protease 7 is a drug-able target that promotes hepatocellular carcinoma and chemoresistance

BACKGROUND: Ubiquitin-specific protease 7 (USP7) is a de-ubiquitin enzyme that plays an essential role in multiple cancers and becomes a target for treatment. However, the role of USP7 and its therapeutic value for HCC remains unclear. METHODS: USP7 expression was examined in HCC tissues by western...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Wei, Zhang, Jingxin, Xu, Chenzhou, Zhang, Shiqing, Bian, Saiyan, Jiang, Feng, Ni, Wenkai, Qu, Lishuai, Lu, Cuihua, Ni, Runzhou, Fan, Yihui, Xiao, Mingbing, Liu, Jinxia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Primary Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6986148/ https://www.ncbi.nlm.nih.gov/pubmed/32002017 http://dx.doi.org/10.1186/s12935-020-1109-2

Ejemplares similares

MKP-4 suppresses hepatocarcinogenesis by targeting ERK1/2 pathway
por: Shen, Zhongyi, et al.
Publicado: (2019)

Coupling function of cyclin‐dependent kinase 2 and Septin2 in the promotion of hepatocellular carcinoma
por: Xu, Chenzhou, et al.
Publicado: (2018)

A novel β2-AR/YB-1/β-catenin axis mediates chronic stress-associated metastasis in hepatocellular carcinoma
por: Liu, Jinxia, et al.
Publicado: (2020)

Identification and Validation of Ubiquitin-Specific Proteases as a Novel Prognostic Signature for Hepatocellular Carcinoma
por: Ni, Wenkai, et al.
Publicado: (2021)

USP7 mediates pathological hepatic de novo lipogenesis through promoting stabilization and transcription of ZNF638
por: Ni, Wenkai, et al.
Publicado: (2020)

Identification of prognostic risk factors for pancreatic cancer using bioinformatics analysis
por: Jin, Dandan, et al.
Publicado: (2020)

Identification and Validation of the N6-Methyladenosine RNA Methylation Regulator YTHDF1 as a Novel Prognostic Marker and Potential Target for Hepatocellular Carcinoma
por: Bian, Saiyan, et al.
Publicado: (2020)

Biological testing of chitosan‐collagen‐based porous scaffolds loaded with PLGA/Triamcinolone microspheres for ameliorating endoscopic dissection‐related stenosis in oesophagus
por: Ni, Wenkai, et al.
Publicado: (2021)

DNA primase subunit 1 deteriorated progression of hepatocellular carcinoma by activating AKT/mTOR signaling and UBE2C-mediated P53 ubiquitination
por: Zhu, Mengqi, et al.
Publicado: (2021)

SRPK1 is a poor prognostic indicator and a novel potential therapeutic target for human colorectal cancer
por: Yi, Nan, et al.
Publicado: (2018)

S100A11 promotes human pancreatic cancer PANC-1 cell proliferation and is involved in the PI3K/AKT signaling pathway
por: Xiao, Mingbing, et al.
Publicado: (2018)

Flap endonuclease 1 Facilitated Hepatocellular Carcinoma Progression by Enhancing USP7/MDM2-mediated P53 Inactivation
por: Bian, Saiyan, et al.
Publicado: (2022)

Potential Susceptibility Mutations in C Gene for Hepatitis B-Related Hepatocellular Carcinoma Identified by a Two-Stage Study in Qidong, China
por: Qu, Lishuai, et al.
Publicado: (2016)

The lncRNA B3GALT5-AS1 Functions as an HCC Suppressor by Regulating the miR-934/UFM1 Axis
por: Chen, Erlin, et al.
Publicado: (2021)

A role for the NPM1/PTPN14/YAP axis in mediating hypoxia-induced chemoresistance to sorafenib in hepatocellular carcinoma
por: Zhang, Dengke, et al.
Publicado: (2022)

Nanos3, a cancer-germline gene, promotes cell proliferation, migration, chemoresistance, and invasion of human glioblastoma
por: Zhang, Fengyu, et al.
Publicado: (2020)

RelB promotes liver fibrosis via inducing the release of injury‐associated inflammatory cytokines
por: Zhou, Danhua, et al.
Publicado: (2020)

Activity of histone deacetylase inhibitors and an Aurora kinase inhibitor in BCR-ABL-expressing leukemia cells: Combination of HDAC and Aurora inhibitors in BCR-ABL-expressing cells
por: Okabe, Seiichi, et al.
Publicado: (2013)

β-TrCP-mediated ubiquitination and degradation of Dlg5 regulates hepatocellular carcinoma cell proliferation
por: Wang, Dongping, et al.
Publicado: (2019)

A cross-talk between integrin β4 and epidermal growth factor receptor induces gefitinib chemoresistance to gastric cancer
por: Huafeng, Jia, et al.
Publicado: (2018)

STAT3-mediated upregulation of LINC00520 contributed to temozolomide chemoresistance in glioblastoma by interacting with RNA-binding protein LIN28B
por: Yuan, Shuai, et al.
Publicado: (2022)

Extracellular HMGB1 interacts with RAGE and promotes chemoresistance in acute leukemia cells
por: Lai, Weixin, et al.
Publicado: (2021)

Quantitative phosphoproteomic analysis reveals chemoresistance-related proteins and signaling pathways induced by rhIL-6 in human osteosarcoma cells
por: Zhang, Rui, et al.
Publicado: (2021)

miR-125b develops chemoresistance in Ewing sarcoma/primitive neuroectodermal tumor
por: Iida, Keiichiro, et al.
Publicado: (2013)

RAC3 influences the chemoresistance of colon cancer cells through autophagy and apoptosis inhibition
por: Rubio, María Fernanda, et al.
Publicado: (2017)

USP7 inhibition induces apoptosis in glioblastoma by enhancing ubiquitination of ARF4
por: Pan, Tingzheng, et al.
Publicado: (2021)

The endoribonuclease N4BP1 prevents psoriasis by controlling both keratinocytes proliferation and neutrophil infiltration
por: Gou, Chenliang, et al.
Publicado: (2021)

The stem cell factor antibody enhances the chemotherapeutic effect of adriamycin on chemoresistant breast cancer cells
por: Jelly, Neil D, et al.
Publicado: (2012)

Hedgehog/Gli1 signaling pathway regulates MGMT expression and chemoresistance to temozolomide in human glioblastoma
por: Wang, Ke, et al.
Publicado: (2017)

Eukaryotic translation initiation factor 5A2 (eIF5A2) regulates chemoresistance in colorectal cancer through epithelial mesenchymal transition
por: Bao, Ying, et al.
Publicado: (2015)

Transcriptional regulation and ubiquitination-dependent regulation of HnRNPK oncogenic function in prostate tumorigenesis
por: Wu, Huan-Lei, et al.
Publicado: (2021)

Oxidative stress-induced chromosome breaks within the ABL gene: a model for chromosome rearrangement in nasopharyngeal carcinoma
por: Tan, Sang-Nee, et al.
Publicado: (2018)

LncRNA SNHG12 regulates the radiosensitivity of cervical cancer through the miR-148a/CDK1 pathway
por: Wang, Chen, et al.
Publicado: (2020)

Deciphering molecular mechanisms underlying chemoresistance in relapsed AML patients: towards precision medicine overcoming drug resistance
por: Levin, May, et al.
Publicado: (2021)

LncRNA SNHG6 promotes chemoresistance through ULK1-induced autophagy by sponging miR-26a-5p in colorectal cancer cells
por: Wang, Xinke, et al.
Publicado: (2019)

KIAA0101, a target gene of miR-429, enhances migration and chemoresistance of epithelial ovarian cancer cells
por: Chen, Hong, et al.
Publicado: (2016)

Uev1A promotes breast cancer cell survival and chemoresistance through the AKT-FOXO1-BIM pathway
por: Wu, Zhaojia, et al.
Publicado: (2019)

JOSD1 promotes proliferation and chemoresistance of head and neck squamous cell carcinoma under the epigenetic regulation of BRD4
por: Jing, Chao, et al.
Publicado: (2021)

The targetable role of herpes virus-associated ubiquitin-specific protease (HAUSP) in p190 BCR-ABL leukemia
por: Carrà, Giovanna, et al.
Publicado: (2016)

p53 sensitizes chemoresistant non-small cell lung cancer via elevation of reactive oxygen species and suppression of EGFR/PI3K/AKT signaling
por: Zhang, Yize, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_28p24stp30s1f24jjkjgda19po