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TNFα-Signaling Modulates the Kinase Activity of Human Effector Treg and Regulates IL-17A Expression

Maintenance of regulatory T cells CD4(+)CD25(high)FOXP3(+) (Treg) stability is vital for proper Treg function and controlling the immune equilibrium. Treg cells are heterogeneous and can reveal plasticity, exemplified by their potential to express IL-17A. TNFα-TNFR2 signaling controls IL-17A express...

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Detalles Bibliográficos
Autores principales:	Urbano, Paulo C. M., He, Xuehui, van Heeswijk, Bennie, Filho, Omar P. S., Tijssen, Henk, Smeets, Ruben L., Joosten, Irma, Koenen, Hans J. P. M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6986271/ https://www.ncbi.nlm.nih.gov/pubmed/32038615 http://dx.doi.org/10.3389/fimmu.2019.03047

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