Anti-inflammatory activity of Anthemis tricolor Boiss

INTRODUCTION: Traditionally, Anthemis genus has been used for the treatment of gastrointestinal disorders, haemorrhoid and stomach ache in Europe. There are several in-vitro and in-vivo studies that showed the pharmacological properties of Anthemisspecies such as antibacterial, anti-inflammatory, antiedemic and hepatoprotective properties. AIM: Our study referred to the model of inflammation formed in rats; we aimed to evaluate anti-inflammatory properties of A. tricolor extracts. MATERIAL AND METHODS: Five different extracts of A. tricolor were tested against the negative control and 2 different topical corticosteroids (betamethasone and hydrocortisone); n-hexane and sesquiterpene extracts of A. tricolorBois showed significantly reduced erythema compared to the negative control. RESULTS: Only n-hexane and sesquiterpene extracts of A. tricolor have the anti-inflammatory effect. CONCLUSIONS: This is the first report on anti-inflammatory activity of A. tricolor and we showed an anti-inflammatory effect of n-hexane and sesquiterpene extract of A. tricolor with UV erythema test as a result, hence A. tricolor extracts can be used for the treatment of inflammatory skin diseases due to anti-inflammatory activity.