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An update on direct immunofluorescence for diagnosing dermatitis herpetiformis
This mini-review presents an update on the direct immunofluorescence (DIF) for diagnosing dermatitis herpetiformis. The DIF of uninvolved, perilesional skin is a crucial laboratory procedure in diagnosing dermatitis herpetiformis (DH). IgA deposits at the dermal-epidermal junction (DEJ) of perilesio...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Termedia Publishing House
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6986300/ https://www.ncbi.nlm.nih.gov/pubmed/31997990 http://dx.doi.org/10.5114/ada.2019.91415 |
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author | Dmochowski, Marian Gornowicz-Porowska, Justyna Bowszyc-Dmochowska, Monika |
author_facet | Dmochowski, Marian Gornowicz-Porowska, Justyna Bowszyc-Dmochowska, Monika |
author_sort | Dmochowski, Marian |
collection | PubMed |
description | This mini-review presents an update on the direct immunofluorescence (DIF) for diagnosing dermatitis herpetiformis. The DIF of uninvolved, perilesional skin is a crucial laboratory procedure in diagnosing dermatitis herpetiformis (DH). IgA deposits at the dermal-epidermal junction (DEJ) of perilesional skin with DIF can also be found in coeliac patients with inflammatory skin diseases different from DH. In certain patients presenting with the rash resembling DH, the deposition of exclusively C3 at DEJ can be found. The term “granular C3 dermatosis” was proposed to name such a rash. Recent data on DH suggest that perhaps the very concept of DH that we are universally accepting now is misleading and should be revised. |
format | Online Article Text |
id | pubmed-6986300 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Termedia Publishing House |
record_format | MEDLINE/PubMed |
spelling | pubmed-69863002020-01-29 An update on direct immunofluorescence for diagnosing dermatitis herpetiformis Dmochowski, Marian Gornowicz-Porowska, Justyna Bowszyc-Dmochowska, Monika Postepy Dermatol Alergol Review Paper This mini-review presents an update on the direct immunofluorescence (DIF) for diagnosing dermatitis herpetiformis. The DIF of uninvolved, perilesional skin is a crucial laboratory procedure in diagnosing dermatitis herpetiformis (DH). IgA deposits at the dermal-epidermal junction (DEJ) of perilesional skin with DIF can also be found in coeliac patients with inflammatory skin diseases different from DH. In certain patients presenting with the rash resembling DH, the deposition of exclusively C3 at DEJ can be found. The term “granular C3 dermatosis” was proposed to name such a rash. Recent data on DH suggest that perhaps the very concept of DH that we are universally accepting now is misleading and should be revised. Termedia Publishing House 2019-12-30 2019-12 /pmc/articles/PMC6986300/ /pubmed/31997990 http://dx.doi.org/10.5114/ada.2019.91415 Text en Copyright © 2019 Termedia http://creativecommons.org/licenses/by-nc-sa/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0). License (http://creativecommons.org/licenses/by-nc-sa/4.0/) |
spellingShingle | Review Paper Dmochowski, Marian Gornowicz-Porowska, Justyna Bowszyc-Dmochowska, Monika An update on direct immunofluorescence for diagnosing dermatitis herpetiformis |
title | An update on direct immunofluorescence for diagnosing dermatitis herpetiformis |
title_full | An update on direct immunofluorescence for diagnosing dermatitis herpetiformis |
title_fullStr | An update on direct immunofluorescence for diagnosing dermatitis herpetiformis |
title_full_unstemmed | An update on direct immunofluorescence for diagnosing dermatitis herpetiformis |
title_short | An update on direct immunofluorescence for diagnosing dermatitis herpetiformis |
title_sort | update on direct immunofluorescence for diagnosing dermatitis herpetiformis |
topic | Review Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6986300/ https://www.ncbi.nlm.nih.gov/pubmed/31997990 http://dx.doi.org/10.5114/ada.2019.91415 |
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