Cargando…

An update on direct immunofluorescence for diagnosing dermatitis herpetiformis

This mini-review presents an update on the direct immunofluorescence (DIF) for diagnosing dermatitis herpetiformis. The DIF of uninvolved, perilesional skin is a crucial laboratory procedure in diagnosing dermatitis herpetiformis (DH). IgA deposits at the dermal-epidermal junction (DEJ) of perilesio...

Descripción completa

Detalles Bibliográficos
Autores principales: Dmochowski, Marian, Gornowicz-Porowska, Justyna, Bowszyc-Dmochowska, Monika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6986300/
https://www.ncbi.nlm.nih.gov/pubmed/31997990
http://dx.doi.org/10.5114/ada.2019.91415
_version_ 1783491955868565504
author Dmochowski, Marian
Gornowicz-Porowska, Justyna
Bowszyc-Dmochowska, Monika
author_facet Dmochowski, Marian
Gornowicz-Porowska, Justyna
Bowszyc-Dmochowska, Monika
author_sort Dmochowski, Marian
collection PubMed
description This mini-review presents an update on the direct immunofluorescence (DIF) for diagnosing dermatitis herpetiformis. The DIF of uninvolved, perilesional skin is a crucial laboratory procedure in diagnosing dermatitis herpetiformis (DH). IgA deposits at the dermal-epidermal junction (DEJ) of perilesional skin with DIF can also be found in coeliac patients with inflammatory skin diseases different from DH. In certain patients presenting with the rash resembling DH, the deposition of exclusively C3 at DEJ can be found. The term “granular C3 dermatosis” was proposed to name such a rash. Recent data on DH suggest that perhaps the very concept of DH that we are universally accepting now is misleading and should be revised.
format Online
Article
Text
id pubmed-6986300
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Termedia Publishing House
record_format MEDLINE/PubMed
spelling pubmed-69863002020-01-29 An update on direct immunofluorescence for diagnosing dermatitis herpetiformis Dmochowski, Marian Gornowicz-Porowska, Justyna Bowszyc-Dmochowska, Monika Postepy Dermatol Alergol Review Paper This mini-review presents an update on the direct immunofluorescence (DIF) for diagnosing dermatitis herpetiformis. The DIF of uninvolved, perilesional skin is a crucial laboratory procedure in diagnosing dermatitis herpetiformis (DH). IgA deposits at the dermal-epidermal junction (DEJ) of perilesional skin with DIF can also be found in coeliac patients with inflammatory skin diseases different from DH. In certain patients presenting with the rash resembling DH, the deposition of exclusively C3 at DEJ can be found. The term “granular C3 dermatosis” was proposed to name such a rash. Recent data on DH suggest that perhaps the very concept of DH that we are universally accepting now is misleading and should be revised. Termedia Publishing House 2019-12-30 2019-12 /pmc/articles/PMC6986300/ /pubmed/31997990 http://dx.doi.org/10.5114/ada.2019.91415 Text en Copyright © 2019 Termedia http://creativecommons.org/licenses/by-nc-sa/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0). License (http://creativecommons.org/licenses/by-nc-sa/4.0/)
spellingShingle Review Paper
Dmochowski, Marian
Gornowicz-Porowska, Justyna
Bowszyc-Dmochowska, Monika
An update on direct immunofluorescence for diagnosing dermatitis herpetiformis
title An update on direct immunofluorescence for diagnosing dermatitis herpetiformis
title_full An update on direct immunofluorescence for diagnosing dermatitis herpetiformis
title_fullStr An update on direct immunofluorescence for diagnosing dermatitis herpetiformis
title_full_unstemmed An update on direct immunofluorescence for diagnosing dermatitis herpetiformis
title_short An update on direct immunofluorescence for diagnosing dermatitis herpetiformis
title_sort update on direct immunofluorescence for diagnosing dermatitis herpetiformis
topic Review Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6986300/
https://www.ncbi.nlm.nih.gov/pubmed/31997990
http://dx.doi.org/10.5114/ada.2019.91415
work_keys_str_mv AT dmochowskimarian anupdateondirectimmunofluorescencefordiagnosingdermatitisherpetiformis
AT gornowiczporowskajustyna anupdateondirectimmunofluorescencefordiagnosingdermatitisherpetiformis
AT bowszycdmochowskamonika anupdateondirectimmunofluorescencefordiagnosingdermatitisherpetiformis
AT dmochowskimarian updateondirectimmunofluorescencefordiagnosingdermatitisherpetiformis
AT gornowiczporowskajustyna updateondirectimmunofluorescencefordiagnosingdermatitisherpetiformis
AT bowszycdmochowskamonika updateondirectimmunofluorescencefordiagnosingdermatitisherpetiformis