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Neuroimaging adolescents with depression in a middle-income country: feasibility of an fMRI protocol and preliminary results

OBJECTIVE: To test the feasibility and to present preliminary results of a neuroimaging protocol to evaluate adolescent depression in a middle-income setting. METHODS: We assessed psychotropic medication-free adolescents (age range 14-16 years) with a diagnosis of major depressive disorder (MDD). Pa...

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Autores principales: Battel, Lucas, Swartz, Johnna, Anes, Mauricio, Manfro, Pedro H., Rohde, Luis A., Viduani, Anna, Mondelli, Valeria, Kieling, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Associação Brasileira de Psiquiatria 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6986476/
https://www.ncbi.nlm.nih.gov/pubmed/31389498
http://dx.doi.org/10.1590/1516-4446-2019-0508
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author Battel, Lucas
Swartz, Johnna
Anes, Mauricio
Manfro, Pedro H.
Rohde, Luis A.
Viduani, Anna
Mondelli, Valeria
Kieling, Christian
author_facet Battel, Lucas
Swartz, Johnna
Anes, Mauricio
Manfro, Pedro H.
Rohde, Luis A.
Viduani, Anna
Mondelli, Valeria
Kieling, Christian
author_sort Battel, Lucas
collection PubMed
description OBJECTIVE: To test the feasibility and to present preliminary results of a neuroimaging protocol to evaluate adolescent depression in a middle-income setting. METHODS: We assessed psychotropic medication-free adolescents (age range 14-16 years) with a diagnosis of major depressive disorder (MDD). Participants underwent a comprehensive clinical evaluation and both structural and functional magnetic resonance imaging (fMRI). In this pilot study, a preliminary single-group analysis of resting-state fMRI (rs-fMRI) data was performed, with a focus on the default mode network (DMN), cognitive control network (CCN), and salience network (SN). RESULTS: The sample included 29 adolescents with MDD (mean age 16.01, SD 0.78) who completed the protocol. Only two participants were excluded due to MRI quality issues (head movement), and were not included in the analyses. The scans showed significant connectivity between the medial prefrontal cortex and posterior cingulate cortex (DMN), the ACC and anterior insula (SN), and the lateral prefrontal cortex and dorsal parietal cortex (CCN). CONCLUSION: We demonstrated the feasibility of implementing a complex neuroimaging protocol in a middle-income country. Further, our preliminary rs-fMRI data revealed patterns of resting-state connectivity consistent with prior research performed in adolescents from high-income countries.
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spelling pubmed-69864762020-01-29 Neuroimaging adolescents with depression in a middle-income country: feasibility of an fMRI protocol and preliminary results Battel, Lucas Swartz, Johnna Anes, Mauricio Manfro, Pedro H. Rohde, Luis A. Viduani, Anna Mondelli, Valeria Kieling, Christian Braz J Psychiatry Original Article OBJECTIVE: To test the feasibility and to present preliminary results of a neuroimaging protocol to evaluate adolescent depression in a middle-income setting. METHODS: We assessed psychotropic medication-free adolescents (age range 14-16 years) with a diagnosis of major depressive disorder (MDD). Participants underwent a comprehensive clinical evaluation and both structural and functional magnetic resonance imaging (fMRI). In this pilot study, a preliminary single-group analysis of resting-state fMRI (rs-fMRI) data was performed, with a focus on the default mode network (DMN), cognitive control network (CCN), and salience network (SN). RESULTS: The sample included 29 adolescents with MDD (mean age 16.01, SD 0.78) who completed the protocol. Only two participants were excluded due to MRI quality issues (head movement), and were not included in the analyses. The scans showed significant connectivity between the medial prefrontal cortex and posterior cingulate cortex (DMN), the ACC and anterior insula (SN), and the lateral prefrontal cortex and dorsal parietal cortex (CCN). CONCLUSION: We demonstrated the feasibility of implementing a complex neuroimaging protocol in a middle-income country. Further, our preliminary rs-fMRI data revealed patterns of resting-state connectivity consistent with prior research performed in adolescents from high-income countries. Associação Brasileira de Psiquiatria 2019-08-05 /pmc/articles/PMC6986476/ /pubmed/31389498 http://dx.doi.org/10.1590/1516-4446-2019-0508 Text en http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Battel, Lucas
Swartz, Johnna
Anes, Mauricio
Manfro, Pedro H.
Rohde, Luis A.
Viduani, Anna
Mondelli, Valeria
Kieling, Christian
Neuroimaging adolescents with depression in a middle-income country: feasibility of an fMRI protocol and preliminary results
title Neuroimaging adolescents with depression in a middle-income country: feasibility of an fMRI protocol and preliminary results
title_full Neuroimaging adolescents with depression in a middle-income country: feasibility of an fMRI protocol and preliminary results
title_fullStr Neuroimaging adolescents with depression in a middle-income country: feasibility of an fMRI protocol and preliminary results
title_full_unstemmed Neuroimaging adolescents with depression in a middle-income country: feasibility of an fMRI protocol and preliminary results
title_short Neuroimaging adolescents with depression in a middle-income country: feasibility of an fMRI protocol and preliminary results
title_sort neuroimaging adolescents with depression in a middle-income country: feasibility of an fmri protocol and preliminary results
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6986476/
https://www.ncbi.nlm.nih.gov/pubmed/31389498
http://dx.doi.org/10.1590/1516-4446-2019-0508
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