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Neuroimaging adolescents with depression in a middle-income country: feasibility of an fMRI protocol and preliminary results
OBJECTIVE: To test the feasibility and to present preliminary results of a neuroimaging protocol to evaluate adolescent depression in a middle-income setting. METHODS: We assessed psychotropic medication-free adolescents (age range 14-16 years) with a diagnosis of major depressive disorder (MDD). Pa...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Associação Brasileira de Psiquiatria
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6986476/ https://www.ncbi.nlm.nih.gov/pubmed/31389498 http://dx.doi.org/10.1590/1516-4446-2019-0508 |
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author | Battel, Lucas Swartz, Johnna Anes, Mauricio Manfro, Pedro H. Rohde, Luis A. Viduani, Anna Mondelli, Valeria Kieling, Christian |
author_facet | Battel, Lucas Swartz, Johnna Anes, Mauricio Manfro, Pedro H. Rohde, Luis A. Viduani, Anna Mondelli, Valeria Kieling, Christian |
author_sort | Battel, Lucas |
collection | PubMed |
description | OBJECTIVE: To test the feasibility and to present preliminary results of a neuroimaging protocol to evaluate adolescent depression in a middle-income setting. METHODS: We assessed psychotropic medication-free adolescents (age range 14-16 years) with a diagnosis of major depressive disorder (MDD). Participants underwent a comprehensive clinical evaluation and both structural and functional magnetic resonance imaging (fMRI). In this pilot study, a preliminary single-group analysis of resting-state fMRI (rs-fMRI) data was performed, with a focus on the default mode network (DMN), cognitive control network (CCN), and salience network (SN). RESULTS: The sample included 29 adolescents with MDD (mean age 16.01, SD 0.78) who completed the protocol. Only two participants were excluded due to MRI quality issues (head movement), and were not included in the analyses. The scans showed significant connectivity between the medial prefrontal cortex and posterior cingulate cortex (DMN), the ACC and anterior insula (SN), and the lateral prefrontal cortex and dorsal parietal cortex (CCN). CONCLUSION: We demonstrated the feasibility of implementing a complex neuroimaging protocol in a middle-income country. Further, our preliminary rs-fMRI data revealed patterns of resting-state connectivity consistent with prior research performed in adolescents from high-income countries. |
format | Online Article Text |
id | pubmed-6986476 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Associação Brasileira de Psiquiatria |
record_format | MEDLINE/PubMed |
spelling | pubmed-69864762020-01-29 Neuroimaging adolescents with depression in a middle-income country: feasibility of an fMRI protocol and preliminary results Battel, Lucas Swartz, Johnna Anes, Mauricio Manfro, Pedro H. Rohde, Luis A. Viduani, Anna Mondelli, Valeria Kieling, Christian Braz J Psychiatry Original Article OBJECTIVE: To test the feasibility and to present preliminary results of a neuroimaging protocol to evaluate adolescent depression in a middle-income setting. METHODS: We assessed psychotropic medication-free adolescents (age range 14-16 years) with a diagnosis of major depressive disorder (MDD). Participants underwent a comprehensive clinical evaluation and both structural and functional magnetic resonance imaging (fMRI). In this pilot study, a preliminary single-group analysis of resting-state fMRI (rs-fMRI) data was performed, with a focus on the default mode network (DMN), cognitive control network (CCN), and salience network (SN). RESULTS: The sample included 29 adolescents with MDD (mean age 16.01, SD 0.78) who completed the protocol. Only two participants were excluded due to MRI quality issues (head movement), and were not included in the analyses. The scans showed significant connectivity between the medial prefrontal cortex and posterior cingulate cortex (DMN), the ACC and anterior insula (SN), and the lateral prefrontal cortex and dorsal parietal cortex (CCN). CONCLUSION: We demonstrated the feasibility of implementing a complex neuroimaging protocol in a middle-income country. Further, our preliminary rs-fMRI data revealed patterns of resting-state connectivity consistent with prior research performed in adolescents from high-income countries. Associação Brasileira de Psiquiatria 2019-08-05 /pmc/articles/PMC6986476/ /pubmed/31389498 http://dx.doi.org/10.1590/1516-4446-2019-0508 Text en http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Battel, Lucas Swartz, Johnna Anes, Mauricio Manfro, Pedro H. Rohde, Luis A. Viduani, Anna Mondelli, Valeria Kieling, Christian Neuroimaging adolescents with depression in a middle-income country: feasibility of an fMRI protocol and preliminary results |
title | Neuroimaging adolescents with depression in a middle-income country: feasibility of an fMRI protocol and preliminary results |
title_full | Neuroimaging adolescents with depression in a middle-income country: feasibility of an fMRI protocol and preliminary results |
title_fullStr | Neuroimaging adolescents with depression in a middle-income country: feasibility of an fMRI protocol and preliminary results |
title_full_unstemmed | Neuroimaging adolescents with depression in a middle-income country: feasibility of an fMRI protocol and preliminary results |
title_short | Neuroimaging adolescents with depression in a middle-income country: feasibility of an fMRI protocol and preliminary results |
title_sort | neuroimaging adolescents with depression in a middle-income country: feasibility of an fmri protocol and preliminary results |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6986476/ https://www.ncbi.nlm.nih.gov/pubmed/31389498 http://dx.doi.org/10.1590/1516-4446-2019-0508 |
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