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Glomerular hyperfiltration is associated with dementia: A nationwide population-based study
BACKGROUND: Glomerular hyperfiltration may be a clinical phenotype of endothelial dysfunction. Endothelial dysfunction may cause vascular dementia through the deterioration of cerebral blood flow. We aimed to identify the risk of dementia in people with glomerular hyperfiltration. METHODS: Using the...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6986766/ https://www.ncbi.nlm.nih.gov/pubmed/31990949 http://dx.doi.org/10.1371/journal.pone.0228361 |
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author | Kang, Min Woo Park, Sehoon Lee, Soojin Lee, Yeonhee Cho, Semin Han, Kyungdo Cho, Hanna Kim, Yaerim Kim, Yong Chul Han, Seung Seok Lee, Hajeong Lee, Jung Pyo Joo, Kwon Wook Lim, Chun Soo Kim, Yon Su Kim, Dong Ki |
author_facet | Kang, Min Woo Park, Sehoon Lee, Soojin Lee, Yeonhee Cho, Semin Han, Kyungdo Cho, Hanna Kim, Yaerim Kim, Yong Chul Han, Seung Seok Lee, Hajeong Lee, Jung Pyo Joo, Kwon Wook Lim, Chun Soo Kim, Yon Su Kim, Dong Ki |
author_sort | Kang, Min Woo |
collection | PubMed |
description | BACKGROUND: Glomerular hyperfiltration may be a clinical phenotype of endothelial dysfunction. Endothelial dysfunction may cause vascular dementia through the deterioration of cerebral blood flow. We aimed to identify the risk of dementia in people with glomerular hyperfiltration. METHODS: Using the Korean National Health Information Database, we included subjects aged ≥45 years who underwent national health screening examinations between 2012 and 2015 and who had no previous history of end-stage renal disease or dementia (n = 2,244,582). The primary exposure was glomerular hyperfiltration. We divided the subjects into groups by sex and five-year age intervals and categorized each group into 8 intervals according to estimated glomerular filtration (eGFR). The subjects with an eGFR ≥95(th) percentile in each group were defined as the hyperfiltration group. The outcomes were development of all types of dementia, Alzheimer's dementia and vascular dementia. Multivariable Cox proportional hazards models were used to analyze the hazard ratios (HRs) for outcomes. RESULTS: The Hyperfiltration group showed a higher risk for the development of all types of dementia [adjusted HR 1.09 (95% CI, 1.03–1.15)] and vascular dementia [adjusted HR 1.33 (95% CI, 1.14–1.55)] than the reference group. However, the association between hyperfiltration and Alzheimer's dementia was not statistically significant. CONCLUSIONS: Glomerular hyperfiltration may be associated with dementia. In this respect, subjects with glomerular hyperfiltration should be monitored more closely for signs and symptoms of dementia. |
format | Online Article Text |
id | pubmed-6986766 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-69867662020-02-18 Glomerular hyperfiltration is associated with dementia: A nationwide population-based study Kang, Min Woo Park, Sehoon Lee, Soojin Lee, Yeonhee Cho, Semin Han, Kyungdo Cho, Hanna Kim, Yaerim Kim, Yong Chul Han, Seung Seok Lee, Hajeong Lee, Jung Pyo Joo, Kwon Wook Lim, Chun Soo Kim, Yon Su Kim, Dong Ki PLoS One Research Article BACKGROUND: Glomerular hyperfiltration may be a clinical phenotype of endothelial dysfunction. Endothelial dysfunction may cause vascular dementia through the deterioration of cerebral blood flow. We aimed to identify the risk of dementia in people with glomerular hyperfiltration. METHODS: Using the Korean National Health Information Database, we included subjects aged ≥45 years who underwent national health screening examinations between 2012 and 2015 and who had no previous history of end-stage renal disease or dementia (n = 2,244,582). The primary exposure was glomerular hyperfiltration. We divided the subjects into groups by sex and five-year age intervals and categorized each group into 8 intervals according to estimated glomerular filtration (eGFR). The subjects with an eGFR ≥95(th) percentile in each group were defined as the hyperfiltration group. The outcomes were development of all types of dementia, Alzheimer's dementia and vascular dementia. Multivariable Cox proportional hazards models were used to analyze the hazard ratios (HRs) for outcomes. RESULTS: The Hyperfiltration group showed a higher risk for the development of all types of dementia [adjusted HR 1.09 (95% CI, 1.03–1.15)] and vascular dementia [adjusted HR 1.33 (95% CI, 1.14–1.55)] than the reference group. However, the association between hyperfiltration and Alzheimer's dementia was not statistically significant. CONCLUSIONS: Glomerular hyperfiltration may be associated with dementia. In this respect, subjects with glomerular hyperfiltration should be monitored more closely for signs and symptoms of dementia. Public Library of Science 2020-01-28 /pmc/articles/PMC6986766/ /pubmed/31990949 http://dx.doi.org/10.1371/journal.pone.0228361 Text en © 2020 Kang et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Kang, Min Woo Park, Sehoon Lee, Soojin Lee, Yeonhee Cho, Semin Han, Kyungdo Cho, Hanna Kim, Yaerim Kim, Yong Chul Han, Seung Seok Lee, Hajeong Lee, Jung Pyo Joo, Kwon Wook Lim, Chun Soo Kim, Yon Su Kim, Dong Ki Glomerular hyperfiltration is associated with dementia: A nationwide population-based study |
title | Glomerular hyperfiltration is associated with dementia: A nationwide population-based study |
title_full | Glomerular hyperfiltration is associated with dementia: A nationwide population-based study |
title_fullStr | Glomerular hyperfiltration is associated with dementia: A nationwide population-based study |
title_full_unstemmed | Glomerular hyperfiltration is associated with dementia: A nationwide population-based study |
title_short | Glomerular hyperfiltration is associated with dementia: A nationwide population-based study |
title_sort | glomerular hyperfiltration is associated with dementia: a nationwide population-based study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6986766/ https://www.ncbi.nlm.nih.gov/pubmed/31990949 http://dx.doi.org/10.1371/journal.pone.0228361 |
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