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Neutralizing Antibodies against Enteroviruses in Patients with Hand, Foot and Mouth Disease

Hand, foot and mouth disease (HFMD) is an emerging infection with pandemic potential. Knowledge of neutralizing antibody responses among its pathogens is essential to inform vaccine development and epidemiologic research. We used 120 paired-plasma samples collected at enrollment and >7 days after...

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Autores principales: Nguyet, Lam Anh, Thanh, Tran Tan, Nhan, Le Nguyen Thanh, Hong, Nguyen Thi Thu, Nhu, Le Nguyen Truc, Van, Hoang Minh Tu, Ny, Nguyen Thi Han, Anh, Nguyen To, Han, Do Duong Kim, Tuan, Ha Manh, Huy, Vu Quang, Viet, Ho Lu, Cuong, Hoang Quoc, Thao, Nguyen Thi Thanh, Viet, Do Chau, Khanh, Truong Huu, Thwaites, Louise, Clapham, Hannah, Hung, Nguyen Thanh, Chau, Nguyen Van Vinh, Thwaites, Guy, Ha, Do Quang, van Doorn, H. Rogier, Tan, Le Van
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6986819/
https://www.ncbi.nlm.nih.gov/pubmed/31961293
http://dx.doi.org/10.3201/eid2602.190721
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author Nguyet, Lam Anh
Thanh, Tran Tan
Nhan, Le Nguyen Thanh
Hong, Nguyen Thi Thu
Nhu, Le Nguyen Truc
Van, Hoang Minh Tu
Ny, Nguyen Thi Han
Anh, Nguyen To
Han, Do Duong Kim
Tuan, Ha Manh
Huy, Vu Quang
Viet, Ho Lu
Cuong, Hoang Quoc
Thao, Nguyen Thi Thanh
Viet, Do Chau
Khanh, Truong Huu
Thwaites, Louise
Clapham, Hannah
Hung, Nguyen Thanh
Chau, Nguyen Van Vinh
Thwaites, Guy
Ha, Do Quang
van Doorn, H. Rogier
Tan, Le Van
author_facet Nguyet, Lam Anh
Thanh, Tran Tan
Nhan, Le Nguyen Thanh
Hong, Nguyen Thi Thu
Nhu, Le Nguyen Truc
Van, Hoang Minh Tu
Ny, Nguyen Thi Han
Anh, Nguyen To
Han, Do Duong Kim
Tuan, Ha Manh
Huy, Vu Quang
Viet, Ho Lu
Cuong, Hoang Quoc
Thao, Nguyen Thi Thanh
Viet, Do Chau
Khanh, Truong Huu
Thwaites, Louise
Clapham, Hannah
Hung, Nguyen Thanh
Chau, Nguyen Van Vinh
Thwaites, Guy
Ha, Do Quang
van Doorn, H. Rogier
Tan, Le Van
author_sort Nguyet, Lam Anh
collection PubMed
description Hand, foot and mouth disease (HFMD) is an emerging infection with pandemic potential. Knowledge of neutralizing antibody responses among its pathogens is essential to inform vaccine development and epidemiologic research. We used 120 paired-plasma samples collected at enrollment and >7 days after the onset of illness from HFMD patients infected with enterovirus A71 (EV-A71), coxsackievirus A (CVA) 6, CVA10, and CVA16 to study cross neutralization. For homotypic viruses, seropositivity increased from <60% at enrollment to 97%–100% at follow-up, corresponding to seroconversion rates of 57%–93%. Seroconversion for heterotypic viruses was recorded in only 3%–23% of patients. All plasma samples from patients infected with EV-A71 subgenogroup B5 could neutralize the emerging EV-A71 subgenogroup C4. Collectively, our results support previous reports about the potential benefit of EV-A71 vaccine but highlight the necessity of multivalent vaccines to control HFMD.
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spelling pubmed-69868192020-02-06 Neutralizing Antibodies against Enteroviruses in Patients with Hand, Foot and Mouth Disease Nguyet, Lam Anh Thanh, Tran Tan Nhan, Le Nguyen Thanh Hong, Nguyen Thi Thu Nhu, Le Nguyen Truc Van, Hoang Minh Tu Ny, Nguyen Thi Han Anh, Nguyen To Han, Do Duong Kim Tuan, Ha Manh Huy, Vu Quang Viet, Ho Lu Cuong, Hoang Quoc Thao, Nguyen Thi Thanh Viet, Do Chau Khanh, Truong Huu Thwaites, Louise Clapham, Hannah Hung, Nguyen Thanh Chau, Nguyen Van Vinh Thwaites, Guy Ha, Do Quang van Doorn, H. Rogier Tan, Le Van Emerg Infect Dis Research Hand, foot and mouth disease (HFMD) is an emerging infection with pandemic potential. Knowledge of neutralizing antibody responses among its pathogens is essential to inform vaccine development and epidemiologic research. We used 120 paired-plasma samples collected at enrollment and >7 days after the onset of illness from HFMD patients infected with enterovirus A71 (EV-A71), coxsackievirus A (CVA) 6, CVA10, and CVA16 to study cross neutralization. For homotypic viruses, seropositivity increased from <60% at enrollment to 97%–100% at follow-up, corresponding to seroconversion rates of 57%–93%. Seroconversion for heterotypic viruses was recorded in only 3%–23% of patients. All plasma samples from patients infected with EV-A71 subgenogroup B5 could neutralize the emerging EV-A71 subgenogroup C4. Collectively, our results support previous reports about the potential benefit of EV-A71 vaccine but highlight the necessity of multivalent vaccines to control HFMD. Centers for Disease Control and Prevention 2020-02 /pmc/articles/PMC6986819/ /pubmed/31961293 http://dx.doi.org/10.3201/eid2602.190721 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Research
Nguyet, Lam Anh
Thanh, Tran Tan
Nhan, Le Nguyen Thanh
Hong, Nguyen Thi Thu
Nhu, Le Nguyen Truc
Van, Hoang Minh Tu
Ny, Nguyen Thi Han
Anh, Nguyen To
Han, Do Duong Kim
Tuan, Ha Manh
Huy, Vu Quang
Viet, Ho Lu
Cuong, Hoang Quoc
Thao, Nguyen Thi Thanh
Viet, Do Chau
Khanh, Truong Huu
Thwaites, Louise
Clapham, Hannah
Hung, Nguyen Thanh
Chau, Nguyen Van Vinh
Thwaites, Guy
Ha, Do Quang
van Doorn, H. Rogier
Tan, Le Van
Neutralizing Antibodies against Enteroviruses in Patients with Hand, Foot and Mouth Disease
title Neutralizing Antibodies against Enteroviruses in Patients with Hand, Foot and Mouth Disease
title_full Neutralizing Antibodies against Enteroviruses in Patients with Hand, Foot and Mouth Disease
title_fullStr Neutralizing Antibodies against Enteroviruses in Patients with Hand, Foot and Mouth Disease
title_full_unstemmed Neutralizing Antibodies against Enteroviruses in Patients with Hand, Foot and Mouth Disease
title_short Neutralizing Antibodies against Enteroviruses in Patients with Hand, Foot and Mouth Disease
title_sort neutralizing antibodies against enteroviruses in patients with hand, foot and mouth disease
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6986819/
https://www.ncbi.nlm.nih.gov/pubmed/31961293
http://dx.doi.org/10.3201/eid2602.190721
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